Hawkins J
Department of Psychology, San Jose State University, CA 95192-0120.
Physiol Behav. 1987;40(6):725-9. doi: 10.1016/0031-9384(87)90274-5.
Rat swimming behaviors have been productive in both sleep research and neuropharmacology. In this report, both of these areas are addressed in the context of inbred strain effects. Thirty-two rats from three stocks were tested in a seven day, repeated measures design. Each rat swam for 5 min each day in shallow 25 degrees C water. There were significant differences between inbred stocks on two measures which can be related to both REM sleep deprivation and adrenergic drug effects. Nonsignificant strain differences were found on two other behaviors which also lack significance under REM sleep deprivation and atropine sulfate treatments. It is concluded that there may be differential stress affecting the treatment-sensitive and the change-resistant behaviors.
大鼠游泳行为在睡眠研究和神经药理学方面都有成效。在本报告中，这两个领域都在近交系效应的背景下进行了探讨。来自三个种群的32只大鼠在为期七天的重复测量设计中接受了测试。每只大鼠每天在25摄氏度的浅水中游泳5分钟。在两项测量中，近交系种群之间存在显著差异，这两项测量可能与快速眼动睡眠剥夺和肾上腺素能药物效应都有关。在另外两项行为上发现了不显著的品系差异，这两项行为在快速眼动睡眠剥夺和硫酸阿托品治疗下也不显著。得出的结论是，可能存在不同的应激影响对治疗敏感和抗变化的行为。
