Hawkins J
Experientia. 1986 Feb 15;42(2):134-6. doi: 10.1007/BF01952432.
Over the past few years, our laboratory group has elaborated a repeated measures rat swimming test. It provides an animal base for showing that the REM sleep mechanism is important to both emotional responsiveness and environmental adaptations. All of that work has been done with Sprague-Dawley rats obtained from a local supplier. Work done with two European rat stocks (by researchers in France and The Netherlands) shows general agreement with our own. In this presentation, we directly compare rats derived from an English vendor's Sprague-Dawley stock with the U.S. based Sprague-Dawley stock which we have been using. We also make strain comparisons via the F344 and the Long Evans strains. Although the literature has numerous examples of swimming test differences between inbred and wild rat stocks, strain difference effects have not been reported. We report that there are significant differences attributable to inbred strain but not to vendor on this measure.
在过去几年里，我们实验室团队精心设计了一项重复测量大鼠游泳测试。该测试为证明快速眼动睡眠机制对情绪反应和环境适应都很重要提供了动物基础。所有这些工作都是使用从当地供应商处获得的斯普拉格-道利大鼠完成的。法国和荷兰的研究人员对两种欧洲大鼠品系所做的工作与我们自己的工作总体一致。在本报告中，我们将直接比较来自英国供应商的斯普拉格-道利品系大鼠与我们一直在使用的美国斯普拉格-道利品系大鼠。我们还通过F344和长爪沙鼠品系进行品系比较。尽管文献中有许多关于近交系和野生大鼠品系游泳测试差异的例子，但尚未有品系差异影响的报道。我们报告称，在这项测量中，存在可归因于近交系品系而非供应商的显著差异。
