Franklin K B, Wolfe J
Department of Psychology, McGill University, Montreal, Quebec, Canada.
Physiol Behav. 1987;40(6):741-5. doi: 10.1016/0031-9384(87)90277-0.
In animals with lesions in the medial or lateral portions of the substantia nigra pars compacta (SNC) amphetamine produces circling in opposite directions. The present study examined the relationships between lesion site and the direction of circling using glyoxylic acid histofluorescence to visualize DA cells. Lesions were produced by 6-hydroxydopamine (2-6 micrograms) or 0.05% ascorbate injected into the SN. After lesions in the medial SNC, amphetamine caused rats to circle ipsiversive to the lesion while after lateral SNC lesions rats circled contraversively. When the lesion extended to the middle of the SNC, or deeper into the SN pars reticulata (SNR), the direction of circling was unpredictable. When the damage produced by the cannula track and ascorbate injection was in the lateral SNR animals circled ipsiversively while medial SNR damage led to contraversive circling. Thus the medial and lateral SN, and the pars compacta and pars reticulata, are functionally antagonistic. This four way division of the SN is consistent with the topographic mapping of SNC to striatum and striatum to SNR.
在黑质致密部（SNC）内侧或外侧部分有损伤的动物中，苯丙胺会引起向相反方向的转圈行为。本研究使用乙醛酸组织荧光法来可视化多巴胺能（DA）细胞，从而研究损伤部位与转圈方向之间的关系。损伤是通过将6-羟基多巴胺（2-6微克）或0.05%抗坏血酸注射到黑质中产生的。内侧SNC损伤后，苯丙胺会使大鼠向损伤同侧转圈，而外侧SNC损伤后，大鼠会向损伤对侧转圈。当损伤扩展到SNC中部或更深地进入黑质网状部（SNR）时，转圈方向无法预测。当套管轨迹和抗坏血酸注射造成的损伤位于外侧SNR时，动物会向同侧转圈，而内侧SNR损伤则导致向对侧转圈。因此，黑质的内侧和外侧以及致密部和网状部在功能上是拮抗的。黑质的这种四分法与SNC到纹状体以及纹状体到SNR的拓扑映射是一致的。
