Vaccarino F J, Franklin K B
Pharmacol Biochem Behav. 1984 Jul;21(1):73-7. doi: 10.1016/0091-3057(84)90133-3.
In combination with systemic d-amphetamine (1 mg/kg), apomorphine or alpha-flupenthixol were unilaterally injected into either the medial or lateral substantia nigra pars compacta (SNC) of adult male hooded rats. Direction and magnitude of circling were measured. Alpha-flupenthixol (5 and 15 micrograms) injected into the medial SNC caused rats to circle contraversive to the injected side while laterally placed injections produced ipsiversive circling. Apomorphine (5 and 15 micrograms) induced ipsiversive circling when injected into the medial SNC but had no effect in the lateral SNC. The results show that nigrostriatal mediated circling can be induced by modulation of dopamine (DA) receptors in the SNC. Furthermore, the findings support the notion that lateral SNC DA neurons are functionally antagonistic to medial SNC DA neurons with respect to circling. The results also suggest that there may be medial-lateral SNC differences in the type of DA receptors.
将阿扑吗啡或α-氟哌噻吨与系统性右旋苯丙胺（1毫克/千克）联合，单侧注射到成年雄性有帽大鼠的内侧或外侧黑质致密部（SNC）。测量转圈的方向和幅度。注射到内侧SNC的α-氟哌噻吨（5微克和15微克）使大鼠向注射侧的对侧转圈，而外侧注射则产生向注射侧的转圈。注射到内侧SNC的阿扑吗啡（5微克和15微克）诱导向注射侧的转圈，但在外侧SNC中没有作用。结果表明，黑质纹状体介导的转圈可通过调节SNC中的多巴胺（DA）受体来诱导。此外，这些发现支持这样的观点，即就转圈而言，外侧SNC多巴胺能神经元在内侧SNC多巴胺能神经元方面具有功能拮抗作用。结果还表明，DA受体类型在SNC内侧-外侧可能存在差异。
