Lee R C, Kolodney M S
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge.
Plast Reconstr Surg. 1987 Nov;80(5):672-9. doi: 10.1097/00006534-198711000-00002.
Electric fields are capable of damaging cells through both thermal and nonthermal mechanisms. While joule heating is generally recognized to mediate tissue injury in electrical trauma, the possible role of electrical breakdown of cell membranes has not been thoroughly considered. Evidence is presented suggestive that in many instances of electrical trauma the local electrical field is of sufficient magnitude to cause electrical breakdown of cell membranes and cell lysis. In theory, large cells such as muscle and nerve cells are more vulnerable to electrical breakdown. To illustrate the significance of cell size and orientation, a geometrically simple model of an elongated cell is analyzed.
电场能够通过热机制和非热机制损伤细胞。虽然焦耳热通常被认为是电创伤中介导组织损伤的原因，但细胞膜电击穿的可能作用尚未得到充分考虑。有证据表明，在许多电创伤情况下，局部电场强度足以导致细胞膜电击穿和细胞裂解。理论上，诸如肌肉和神经细胞等大型细胞更容易受到电击穿的影响。为了说明细胞大小和取向的重要性，分析了一个几何形状简单的细长细胞模型。
