Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
Cancer Sci. 2023 Jan;114(1):201-210. doi: 10.1111/cas.15490. Epub 2022 Nov 14.
Since 2020, the coronavirus disease 2019 pandemic has led to the widespread practice of hand hygiene and wearing face masks, not only among medical personnel, but also among the general population. Thus, the impact of the coronavirus disease 2019 pandemic on the incidence of febrile neutropenia should be verified. This study aimed to examine the incidence of febrile neutropenia in hospitalized patients receiving chemotherapy at Kanazawa University Hospital. Among inpatients at the Department of Urology receiving chemotherapy, we compared the incidence of febrile neutropenia between 317 cases in 2018-2019 and 276 cases in 2020. We retrospectively analyzed the factors of febrile neutropenia via binomial logistic regression analysis based on patient characteristics and the characteristics of primary diseases, with statistical significance set at p < 0.05. Febrile neutropenia occurred in 20/317 cases in 2018-2019 and 1/276 cases in 2020, with a significant decrease in the latter (p = 0.005). In a multivariate analysis, we identified the following independent risk factors for febrile neutropenia: non-coronavirus disease 2019 era (p = 0.005), first course of therapy (p = 0.005), malnutrition (p = 0.032), and past history of febrile neutropenia (p = 0.018). Due to the coronavirus disease 2019 pandemic, hygiene policies for medical personnel and quarantine measures for patients were thoroughly implemented. Therefore, the incidence of febrile neutropenia in 2020 decreased to 1/15 of the previous incidence. Thus, the hygiene for medical personnel and patients during the expected period of chemotherapy-induced neutropenia is important for febrile neutropenia prevention.
自 2020 年以来，新型冠状病毒病大流行导致手卫生和戴口罩的广泛实践，不仅在医务人员中，而且在普通人群中也是如此。因此，应该验证新型冠状病毒病大流行对发热性中性粒细胞减少症发病率的影响。本研究旨在检查金泽大学医院接受化疗的住院患者发热性中性粒细胞减少症的发病率。在接受化疗的泌尿科住院患者中，我们比较了 2018-2019 年的 317 例和 2020 年的 276 例发热性中性粒细胞减少症的发病率。我们通过二项逻辑回归分析基于患者特征和主要疾病特征对发热性中性粒细胞减少症的因素进行了回顾性分析，统计学意义设为 p < 0.05。2018-2019 年发生发热性中性粒细胞减少症 20/317 例，2020 年发生发热性中性粒细胞减少症 1/276 例，后者显著减少（p = 0.005）。多变量分析确定发热性中性粒细胞减少症的独立危险因素如下：非新型冠状病毒病 2019 时代（p = 0.005）、第一疗程（p = 0.005）、营养不良（p = 0.032）和发热性中性粒细胞减少症病史（p = 0.018）。由于新型冠状病毒病大流行，医务人员的卫生政策和患者的检疫措施得到了彻底实施。因此，2020 年发热性中性粒细胞减少症的发病率下降到之前发病率的 1/15。因此，在预期的化疗诱导性中性粒细胞减少期间，对医务人员和患者的卫生是预防发热性中性粒细胞减少症的重要措施。
