National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Geriatric Health Care and Medical Research Center, Sichuan University, Chengdu, China.
Gerontology. 2021;67(4):386-396. doi: 10.1159/000513247. Epub 2021 Feb 17.
The aim of this study was to investigate the prevalence and associated factors of sarcopenia defined by different criteria in community-dwelling adults of west China using the baseline data of West-China Health and Aging Trend (WCHAT) study.
Adults aged 50 years or older in communities of Yunnan, Guizhou, Sichuan, and Xinjiang provinces were enrolled in this study. We applied 6 -diagnostic criteria (AWGS 2019, AWGS 2014, EWGSOP1, -EWGSOP2, IWGS, and FNIH) to define sarcopenia. Muscle mass was measured based on bioimpedance analysis. Handgrip strength and walking speed were recorded, respectively. Different variables like anthropometry measures, lifestyles, chronic disease, and blood test were collected.
We included 4,500 participants. The prevalence of sarcopenia was 22.8, 19.3, 57.1, 11.8, 24.1, and 18.1% according to the AWGS 2019, AWGS 2014, EWGSOP 1, EWGSOP 2, IWGS, and FNIH criteria, respectively. We found that serum albumin level was independently associated with sarcopenia using AWGS 2019 and IWGS. And vitamin D level was independently associated with sarcopenia using AWGS 2014, -EWGSOP2, and FNIH. While age, depressive status, BMI, hemoglobin, vitamin D, and insulin level were all significantly associated with sarcopenia using AWGS 2014, but all of these factors were not significant using AWGS 2019.
Sarcopenia was highly prevalent in west China regardless of the diagnostic criteria. Serum albumin and vitamin D level were mostly associated with sarcopenia defined by different criteria. While most risk factors associated with the AWGS 2014-defined sarcopenia exhibited no consistent pattern with AWGS 2019, the validity of the AWGS 2019 consensus needs to be confirmed in further prospective studies.
本研究旨在利用中国西部健康与老龄化趋势研究（WCHAT）的基线数据，调查中国西部社区居住成年人中不同标准定义的肌少症的患病率及相关因素。
本研究纳入了云南省、贵州省、四川省和新疆维吾尔自治区社区中年龄在 50 岁及以上的成年人。我们应用 6 项诊断标准（AWGS 2019、AWGS 2014、EWGSOP1、-EWGSOP2、IWGS 和 FNIH）来定义肌少症。肌肉质量基于生物阻抗分析进行测量。分别记录握力和步行速度。收集了不同的变量，如人体测量指标、生活方式、慢性疾病和血液检查。
我们共纳入了 4500 名参与者。根据 AWGS 2019、AWGS 2014、EWGSOP 1、EWGSOP 2、IWGS 和 FNIH 标准，肌少症的患病率分别为 22.8%、19.3%、57.1%、11.8%、24.1%和 18.1%。我们发现，血清白蛋白水平与 AWGS 2019 和 IWGS 定义的肌少症独立相关。而血清维生素 D 水平与 AWGS 2014、-EWGSOP2 和 FNIH 定义的肌少症独立相关。而年龄、抑郁状态、BMI、血红蛋白、维生素 D 和胰岛素水平均与 AWGS 2014 定义的肌少症显著相关，但这些因素在 AWGS 2019 中均不显著。
无论采用何种诊断标准，肌少症在中国西部都高度流行。血清白蛋白和维生素 D 水平与不同标准定义的肌少症关系最为密切。与 AWGS 2014 定义的肌少症相关的大多数危险因素与 AWGS 2019 无一致模式，AWGS 2019 共识的有效性需要进一步的前瞻性研究来证实。
