Progress and perspectives on microbial electrosynthesis for valorisation of CO into value-added products.

Microbial electrosynthesis (MES) is a neoteric technology that facilitates biocatalysed synthesis of organic compounds with the aid of homoacetogenic bacteria, while feeding CO as an inorganic carbon source. Operating MES with surplus renewable electricity further enhances the sustainability of this innovative bioelectrochemical system (BES). However, several lacunae exist in the domain knowledge, stunting the widespread application of MES. Despite significant progress in this area over the past decade, the product yield efficiency is not on par with other contemporary technologies. This bottleneck can be overcome by adopting a holistic approach, i.e., applying innovative and integrated solutions to ensure a robust MES operation. Further, the widespread deployment of MES exclusively relies on its ability to mature a sessile biofilm over a biocompatible electrode, while offering minimal charge transfer resistance. Additionally, operating MES preferably at H-generating reduction potential and valorising industrial off-gas as carbon substrate is crucial to accomplish economic sustainability. In light of the aforementioned, this review collates the latest progress in the design and development of MES-centred systems for valorisation of CO into value-added products. Specifically, it highlights the significance of inoculum pre-treatment for promoting biocatalytic activity and biofilm growth on the cathodic surface. In addition, it summarizes the diverse materials that are commonly used as electrodes in MES, with an emphasis on the importance of inexpensive, robust, and biocompatible electrode materials for the practical application of MES technology. Further, the review presents insights into media conditions, operational factors, and reactor configurations that affect the overall performance of MES process. Finally, the product range of MES, downstream processing requirements, and integration of MES with other environmental remediation technologies are also discussed.