Université Paris Cité, Université Sorbonne Paris Nord, LVTS, UMRS 1148 INSERM, F- 75018, Paris, France.
Université Paris Cité, Université Sorbonne Paris Nord, LVTS, UMRS 1148 INSERM, F- 75018, Paris, France.
Biomaterials. 2023 Mar;294:122025. doi: 10.1016/j.biomaterials.2023.122025. Epub 2023 Jan 25.
Microbubbles (MBs) were observed for the first time in vivo as a curious consequence of quick saline injection during ultrasound (US) imaging of the aortic root, more than 50 years ago. From this serendipitous event, MBs are now widely used as contrast enhancers for US imaging. Their intrinsic properties described in this review, allow a multitude of designs, from shell to gas composition but also from grafting targeting agents to drug payload encapsulation. Indeed, the versatile MBs are deeply studied for their dual potential in imaging and therapy. As presented in this paper, new generations of MBs now opens perspectives for targeted molecular imaging along with the development of new US imaging systems. This review also presents an overview of the different therapeutic strategies with US and MBs for cancer, cardiovascular diseases, and inflammation. The overall aim is to overlap those fields in order to find similarities in the MBs application for treatment enhancement associated with US. To conclude, this review explores the new scales of MBs technologies with nanobubbles development, and along concurrent advances in the US imaging field. This review ends by discussing perspectives for the booming future uses of MBs.
微泡（MBs）是在 50 多年前进行超声（US）成像主动脉根部时，由于快速注射盐水而偶然观察到的一种奇特现象。从这个偶然事件开始，MBs 现在被广泛用作 US 成像的对比增强剂。本文介绍了其固有特性，允许进行多种设计，从外壳到气体组成，甚至从靶向配体接枝到药物包裹。事实上，多功能的 MBs 在成像和治疗方面具有双重潜力，受到了深入研究。正如本文所述，新一代 MBs 现在为靶向分子成像开辟了前景，同时也为新的 US 成像系统的发展开辟了前景。本文还概述了 US 和 MBs 在癌症、心血管疾病和炎症方面的不同治疗策略。总的来说，目的是将这些领域重叠起来，以发现与 US 相关的治疗增强中 MBs 应用的相似之处。总之，本文探讨了微泡技术与纳米泡发展的新尺度，并结合 US 成像领域的同步进展。本文最后讨论了 MBs 未来应用的前景。
