Fukagawa Tatsuo, Kakutani Tetsuji
Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan. Electronic address: https://twitter.com/tatsuofukagawa1.
Department of Biological Sciences, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.
Curr Opin Genet Dev. 2023 Feb;78:102021. doi: 10.1016/j.gde.2023.102021. Epub 2023 Jan 28.
Epigenetic mechanisms are important not only for development but also for genome stability and chromosome dynamics. The latter types of epigenetic controls can often be transgenerational. Here, we review recent progress in two examples of transgenerational epigenetic control: i) the control of constitutive heterochromatin and transposable elements and ii) epigenetic mechanisms that regulate centromere specification and functions. We also discuss the biological significance of enigmatic associations among centromeres, transposons, and constitutive heterochromatin.
表观遗传机制不仅对发育很重要，而且对基因组稳定性和染色体动态变化也很重要。后一种类型的表观遗传控制通常可以跨代遗传。在这里，我们回顾了跨代表观遗传控制的两个例子的最新进展：i）组成型异染色质和转座元件的控制，以及ii）调节着丝粒特异性和功能的表观遗传机制。我们还讨论了着丝粒、转座子和组成型异染色质之间神秘关联的生物学意义。
