Leonidze D L
Radiobiologiia. 1987 Sep-Oct;27(5):696-9.
In experiments with mice bearing solid sarcoma 37 a study was conducted on the combined effect of radiation and inductors of endogenous interferon synthesis (IEIS), together with hyperthermia or together with an alkylating and carbomoilating agent, dimethinur. The effect was estimated by the tumor growth coefficient and by the number of animals with the regressed tumors. Po I. polyC was not shown to influence the efficiency of hyperthermia combined with radiation; dextransulphate and tiloron increased the radiosensitizing effect of hyperthermia. Dimethinur aggravated the effect of radiation, but with IEIS used together with dimethynur and radiation, the response of the tumor increased insignificantly as compared to the effect of IEIS together with radiation.
在对患有实体肉瘤37的小鼠进行的实验中，开展了一项关于辐射与内源性干扰素合成诱导剂（IEIS）联合作用的研究，该联合作用还包括与热疗联合，或与一种烷基化和羰化剂二甲硝胺联合。通过肿瘤生长系数以及肿瘤消退的动物数量来评估效果。聚肌苷酸 - 聚胞苷酸（Po I. polyC）未显示出对热疗与辐射联合效果的影响；硫酸葡聚糖和泰洛龙增强了热疗的放射增敏作用。二甲硝胺加剧了辐射的效果，但当IEIS与二甲硝胺和辐射一起使用时，与IEIS和辐射联合的效果相比，肿瘤的反应仅略有增加。
