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[甲硝唑、干扰素合成诱导剂与DNA修复抑制剂的联合作用]

[Combined effect of metronidazole, interferon synthesis inducers and DNA repair inhibitors].

作者信息

Leonidze D L, Afanas'ev G G, Khanson K P, Vartanian L P, Poverennyĭ A M

出版信息

Radiobiologiia. 1986 Mar-Apr;26(2):231-5.

PMID:3704119
Abstract

In experiments on mice with solid sarcoma 37, a study was made of modification of the radiosensitizing effect of metronidazole. The increase in the leucotic interferon titre, induced by the interferon synthesis inductors, did not influence the radiosensitizing efficiency of metronidazole: after the administration of the repair inhibitor, 8-bromocaffeine, the coefficient of suppression of tumor growth was higher and the number of mice with the regressed tumors greater as compared to animals affected by metronidazole and radiation.

摘要

在对实体肉瘤37小鼠进行的实验中,对甲硝唑放射增敏作用的改变进行了研究。由干扰素合成诱导剂诱导的白细胞干扰素滴度的增加,并未影响甲硝唑的放射增敏效率:与受甲硝唑和辐射影响的动物相比,给予修复抑制剂8-溴咖啡因后,肿瘤生长抑制系数更高,肿瘤消退的小鼠数量更多。

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1
[Combined effect of metronidazole, interferon synthesis inducers and DNA repair inhibitors].[甲硝唑、干扰素合成诱导剂与DNA修复抑制剂的联合作用]
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