Karakulov R K, Poverennyĭ A M, Ershov F I, Popov G A, Pelevina I I
Vopr Onkol. 1984;30(2):69-76.
Oral administration of a liposome-encapsulated agent triggering the synthesis of interferon--poly(I) poly (C)--to mice bearing solid sarcoma 37 was followed by (a) production of an interferon which circulates for a longer period after preliminary administration of "empty" liposomes; (b) lengthening of the period of tumor latency; in some cases tumor failed to appear at all; (c) higher efficacy of radiation treatment which was manifested by a higher inhibition of tumor growth or complete regression; (d) increased antitumor effect of 5-fluorouracil, and (e) suppression of proliferative activity of tumor.
给患有实体肉瘤37的小鼠口服一种触发干扰素——聚肌苷酸-聚胞苷酸（poly(I) poly (C)）合成的脂质体包裹剂后，出现了以下情况：(a) 在预先给予“空”脂质体后，产生了一种循环时间更长的干扰素；(b) 肿瘤潜伏期延长；在某些情况下，肿瘤根本没有出现；(c) 放射治疗效果增强，表现为对肿瘤生长的更高抑制或完全消退；(d) 5-氟尿嘧啶的抗肿瘤作用增强；以及(e) 肿瘤增殖活性受到抑制。
