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Physiologically based pharmacokinetic modeling to predict OAT3-mediated drug-drug interactions of meropenem in varying stages of chronic kidney disease.

作者信息

Dong Jing, Liu Jinyao, Liu Yanhui, Yao Jiachen, Lu Yan, Jiao Zheng, Li Wenyan

机构信息

Department of Pharmacy, Shanghai Pudong New Area Gongli Hospital, The Second Military Medical University, 219 Miaopu Road, Shanghai 200135, PR China.

Ningxia Medical University, 1160 Shengli Street, Ningxia, Yinchuan 750004, PR China.

出版信息

Eur J Pharm Sci. 2023 Apr 1;183:106395. doi: 10.1016/j.ejps.2023.106395. Epub 2023 Jan 28.

DOI:10.1016/j.ejps.2023.106395
PMID:36716979
Abstract
摘要

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Pharm Res. 2025 Jun 27. doi: 10.1007/s11095-025-03885-5.
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Dosage Optimization Using Physiologically Based Pharmacokinetic Modeling for Pediatric Patients with Renal Impairment: A Case Study of Meropenem.使用基于生理的药代动力学模型对肾功能不全儿科患者进行剂量优化:美罗培南的案例研究
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