Child Study Center, Yale School of Medicine, New Haven, CT 06510, USA; Anxiety and Mood Disorders Program, Yale School of Medicine, New Haven, CT 06510, USA.
Child Study Center, Yale School of Medicine, New Haven, CT 06510, USA; Anxiety and Mood Disorders Program, Yale School of Medicine, New Haven, CT 06510, USA.
J Affect Disord. 2023 Apr 1;326:193-197. doi: 10.1016/j.jad.2023.01.090. Epub 2023 Jan 28.
Recent research implicates fibroblast growth factor 2 (FGF2) in anxiety and depressive symptoms of childhood. This study is the first to examine an intergenerational pathway linking FGF2 levels in mothers to FGF2 levels in children, and to the children's anxiety and depressive symptoms.
We assayed serum FGF2 in 259 mothers and their children, with a range of anxiety and depressive symptoms: 194 were mothers of clinic-referred anxious and depressed children; 65 were mothers of non-referred children. We examined associations between FGF2 levels in mothers and children, and anxiety and depression symptoms. We used structural equation modeling (SEM) to examine associations between maternal and child FGF2 levels, and between maternal and child FGF2 levels and symptoms of anxiety and depression in and children.
FGF2 levels in mothers and children were significantly positively correlated. Children's FGF2 levels were significantly negatively correlated with their ratings of anxiety and depression. Results of the SEM model showed that increases in maternal FGF2 levels were significantly associated with increases in child FGF2, which in turn was associated with decreases in child anxiety and child depression, controlling for maternal anxiety and depression.
We relied on self-reported ratings of anxiety and depression, and on a single measurement of FGF2 levels for each participant.
Our results point to a role for FGF2 in the intergenerational transmission of risk for, and resilience to, anxiety and depression in youth.
最近的研究表明，成纤维细胞生长因子 2（FGF2）与儿童的焦虑和抑郁症状有关。本研究首次检验了一个代际途径，即母亲的 FGF2 水平与儿童的 FGF2 水平以及儿童的焦虑和抑郁症状之间的关系。
我们检测了 259 位母亲及其具有不同焦虑和抑郁症状的孩子的血清 FGF2：194 位是有焦虑和抑郁症状的诊所就诊儿童的母亲；65 位是无就诊儿童的母亲。我们检验了母亲和儿童的 FGF2 水平之间、儿童的 FGF2 水平与焦虑和抑郁症状之间的相关性。我们使用结构方程模型（SEM）来检验母亲和儿童的 FGF2 水平之间的相关性，以及母亲和儿童的 FGF2 水平与儿童的焦虑和抑郁症状之间的相关性。
母亲和儿童的 FGF2 水平呈显著正相关。儿童的 FGF2 水平与他们的焦虑和抑郁评分呈显著负相关。SEM 模型的结果表明，母亲的 FGF2 水平增加与儿童的 FGF2 水平增加显著相关，而儿童的 FGF2 水平增加又与儿童的焦虑和抑郁评分降低显著相关，这一结果在控制了母亲的焦虑和抑郁症状后仍然存在。
我们依赖于参与者的自我报告的焦虑和抑郁评分，以及对每个参与者的单次 FGF2 水平测量。
我们的研究结果表明 FGF2 在儿童的焦虑和抑郁的代际传递中具有风险和韧性作用。
