Pham Truong-Minh, Thanh Nguyen Xuan, Ng Nawi, Kubo Tatsuhiko, Fujino Yoshihisa, Matsuda Shinya, Phan Phuong, Joseph Kurian, Sauvaget Catherine, Walker Emily, Shack Lorraine, Cheung Winson Y
Surveillance and Reporting, Cancer Research and Analytics, Cancer Care Alberta, Alberta Health Services, Edmonton and Calgary, Canada.
Strategic Clinical Networks, Alberta Health Services, Edmonton and Calgary, Canada.
Ann Epidemiol. 2023 Apr;80:76-85. doi: 10.1016/j.annepidem.2023.01.012. Epub 2023 Jan 28.
We applied a novel measure of average lifespan shortened (ALSS) to examine changes in lifespan among patients who died of cancer over a 10-year period from 2006 to 2016 in 20 selected high-income countries from North America, Europe, Asia, and Oceania.
We retrieved cancer deaths in each country from the World Health Organization mortality database. We calculated ALSS as a ratio of years of life lost to the expected lifespan among patients who died from cancer.
Between 2006 and 2016, we observed modest changes in ALSS for overall cancer deaths over the study in many countries. The changes in the ALSS over time due to any cancer ranged between -1.7 and +0.4 percentage points (pps) among men and between -1.9 and +0.6 pps among women. Across countries, overall cancer deaths led to an average loss between 16% and 22% of their lifespan in men, and between 18% and 24% in women. Across cancer sites, patients who died of central nervous system cancers, for instance, lost a large proportion of their lifespan.
In this study, we demonstrated the use of ALSS across selected high-income countries, which enables population-level assessment of premature mortality among cancer patients over time.
我们应用一种新的平均寿命缩短量（ALSS）指标，来研究2006年至2016年这10年间，北美、欧洲、亚洲和大洋洲20个选定高收入国家中死于癌症患者的寿命变化情况。
我们从世界卫生组织死亡率数据库中检索了每个国家的癌症死亡数据。我们将ALSS计算为癌症死亡患者的生命损失年数与预期寿命的比值。
2006年至2016年期间，我们观察到在许多国家的整个研究过程中，总体癌症死亡的ALSS有适度变化。男性因任何癌症导致的ALSS随时间的变化范围在-1.7至+0.4个百分点（pps）之间，女性在-1.9至+0.6 pps之间。在各个国家，总体癌症死亡导致男性平均寿命损失16%至22%，女性为18%至24%。在不同癌症部位中，例如死于中枢神经系统癌症的患者，寿命损失比例很大。
在本研究中，我们展示了在选定的高收入国家中使用ALSS的情况，这能够对癌症患者随时间推移的过早死亡率进行人群水平的评估。
