Clinical Research Academy, Peking University Shenzhen Hospital, Peking University, Shenzhen, Guangdong, China.
Renal Division, Peking University Shenzhen Hospital, Peking University, Shenzhen, China.
J Cachexia Sarcopenia Muscle. 2023 Apr;14(2):992-1002. doi: 10.1002/jcsm.13181. Epub 2023 Jan 30.
Magnetic resonance imaging (MRI) is the gold standard for evaluating body composition. However, the reference ranges have not been established.
Three lean tissue and seven adipose tissue parameters based on MRI data from the UK Biobank were used in this study. Participants with European ancestry and data on at least one parameter were screened. Age- and sex-specific percentile curves were generated using the lambda-mu-sigma method. Three levels of reference ranges were provided, which were equivalent to the mean ± 1 standard deviation (SD), 2 SDs and 2.5 SDs.
The final analysis set for each parameter ranged from 4842 to 14 148 participants (53.4%-56.6% women) with a median age of 61. For lean tissue parameters, compared with those at age 45, the median total lean tissue volume and total thigh fat-free muscle volume at age 70 were 2.83 and 1.73 L, and 3.02 and 1.51 L lower in men and women, respectively. The median weight-to-muscle ratios at age 45 were 0.51 and 0.83 kg/L lower compared with those at age 70 in men and women, respectively. Adipose tissue parameters showed inconsistent differences. In men, the median muscle fat infiltration, visceral adipose tissue (VAT) volume, total abdominal adipose tissue index and abdominal fat ratio were 1.48%, 0.32 L, 0.08 L/m and 0.4 higher, and the median abdominal subcutaneous adipose tissue (ASAT) volume and total adipose tissue volume were 0.47 and 0.41 L lower, respectively, at age 70 than at age 45. The median total trunk fat volume was approximately 9.53 L at all ages. In women, the median muscle fat infiltration and VAT volume were 1.68% and 0.76 L higher, respectively, at age 70 than at age 45. The median ASAT volume, total adipose tissue volume, total trunk fat volume, total abdominal adipose tissue index and abdominal fat ratio were 0.35 L, 0.78 L, 1.12 L, 0.49 L/m and 0.06 higher, respectively, at age 60 than at age 45. The medians of the former three parameters were 0.33 L, 0.14 L and 0.20 L lower, at age 70 than at age 60. The medians of the latter two parameters were approximately 3.64 L/m and 0.55 at ages between 60 and 70.
We have established reference ranges for MRI-measured body composition parameters in a large community-dwelling population. These findings provide a more accurate assessment of abnormal adipose and muscle conditions.
磁共振成像（MRI）是评估人体成分的金标准。然而，尚未建立参考范围。
本研究使用了来自英国生物库的 MRI 数据中的三个瘦组织参数和七个脂肪组织参数。筛选出具有欧洲血统且至少有一个参数数据的参与者。使用 lambda-mu-sigma 方法生成年龄和性别特异性百分位数曲线。提供了三个参考范围级别，分别相当于平均值±1 个标准差（SD）、2 SD 和 2.5 SD。
每个参数的最终分析集范围为 4842 至 14148 名参与者（53.4%-56.6%为女性），中位年龄为 61 岁。对于瘦组织参数，与 45 岁相比，70 岁时男性和女性的总瘦组织体积和总大腿无脂肪肌肉体积分别低 2.83 和 1.73L，男性和女性的体重与肌肉比分别低 0.51 和 0.83kg/L。45 岁时男性和女性的肌肉脂肪浸润、内脏脂肪组织（VAT）体积、全腹脂肪组织指数和腹部脂肪比分别高 1.48%、0.32L、0.08L/m 和 0.4，腹部皮下脂肪组织（ASAT）体积和总脂肪组织体积分别低 0.47 和 0.41L。所有年龄的总躯干脂肪量中位数约为 9.53L。在女性中，70 岁时肌肉脂肪浸润和 VAT 体积分别比 45 岁时高 1.68%和 0.76L。60 岁时女性的 ASAT 体积、总脂肪组织体积、总躯干脂肪量、全腹脂肪组织指数和腹部脂肪比分别高 0.35L、0.78L、1.12L、0.49L/m 和 0.06，70 岁时分别比 60 岁时高 0.33L、0.14L、0.20L。60 岁时，前三个参数的中位数分别比 70 岁时低 0.33L、0.14L 和 0.20L。后两个参数的中位数在 60 岁至 70 岁之间约为 3.64L/m 和 0.55。
我们在一个大型社区人群中建立了 MRI 测量的人体成分参数的参考范围。这些发现为评估异常脂肪和肌肉状况提供了更准确的评估。
