Research Centre for Optimal Health, School of Life Sciences, University of Westminster, London, UK.
Obesity (Silver Spring). 2024 Sep;32(9):1699-1708. doi: 10.1002/oby.24108. Epub 2024 Jul 25.
This study aimed to assess the fatty acid (FA) composition of abdominal subcutaneous and visceral adipose tissue (ASAT and VAT, respectively) in the UK Biobank imaging cohort (N = 33,823) using magnetic resonance imaging (MRI).
We measured the fractions of saturated, monounsaturated, and polyunsaturated FA (fSFA, fMUFA, and fPUFA, respectively) in ASAT and VAT from multiecho MRI scans. We selected a subcohort of participants who followed a vegan and an omnivore diet (N = 36) to validate the effect of diet on adipose tissue. In the wider imaging cohort, we examined the relationships between adipose tissue FA composition and various traits related to disease and body size.
We measured adipose tissue FA composition for over 33,000 participants, revealing higher fSFA and fPUFA and lower fMUFA in VAT (p < 0.00016). fMUFA and fPUFA were higher in ASAT and lower in VAT for women (p < 0.00016). Vegan participants exhibited lower fSFA in both ASAT and VAT (p < 0.00016). VAT fSFA and fMUFA showed significant associations with disease, as well as anthropometric variables.
This extensive analysis revealed the relationships between adipose tissue FA composition and a range of factors in a diverse population, highlighting the importance of studying body adipose tissue beyond its quantity.
本研究旨在使用磁共振成像（MRI）评估英国生物库影像学队列（N=33823）中腹部皮下和内脏脂肪组织（ASAT 和 VAT）的脂肪酸（FA）组成。
我们从多回波 MRI 扫描中测量了 ASAT 和 VAT 中饱和、单不饱和和多不饱和 FA（fSFA、fMUFA 和 fPUFA）的分数。我们选择了遵循素食和杂食饮食的参与者亚组（N=36），以验证饮食对脂肪组织的影响。在更广泛的影像学队列中，我们研究了脂肪组织 FA 组成与与疾病和身体大小相关的各种特征之间的关系。
我们对超过 33000 名参与者进行了脂肪组织 FA 组成的测量，结果显示 VAT 中的 fSFA 和 fPUFA 更高，fMUFA 更低（p<0.00016）。女性 ASAT 中的 fMUFA 和 fPUFA 更高，VAT 中的 fMUFA 和 fPUFA 更低（p<0.00016）。素食参与者的 ASAT 和 VAT 中的 fSFA 均较低（p<0.00016）。VAT 的 fSFA 和 fMUFA 与疾病以及人体测量变量存在显著关联。
这项广泛的分析揭示了脂肪组织 FA 组成与多种因素之间的关系，强调了研究身体脂肪组织除了数量之外的重要性。
