细胞外基质的年龄相关变化
Age-Related Changes in Extracellular Matrix.
作者信息
Guvatova Zulfiia G, Borisov Pavel V, Alekseev Alexey A, Moskalev Alexey A
机构信息
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia.
Russian Clinical Research Center for Gerontology, Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation, Moscow, 129226, Russia.
出版信息
Biochemistry (Mosc). 2022 Dec;87(12):1535-1551. doi: 10.1134/S0006297922120112.
Extracellular matrix (ECM) is an extracellular tissue structure that, in addition to mechanical support to the cell, is involved in regulation of many cellular processes, including chemical transport, growth, migration, differentiation, and cell senescence. Age-related changes in the structure and composition of the matrix and increase of ECM stiffness with age affect functioning of many tissues and contribute to the development of various pathological conditions. This review considers age-related changes of ECM in various tissues and organs, in particular, effect of ECM changes on aging is discussed.
细胞外基质（ECM）是一种细胞外组织结构，除了对细胞提供机械支持外，还参与许多细胞过程的调节，包括化学物质运输、生长、迁移、分化和细胞衰老。随着年龄增长，基质的结构和组成发生变化，且ECM硬度增加，这些都会影响许多组织的功能，并促使各种病理状况的发展。本综述探讨了不同组织和器官中与年龄相关的ECM变化，特别是讨论了ECM变化对衰老的影响。
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