Laboratory of Cell Proliferation and Ageing, Institute of Biosciences and Applications, National Centre for Scientific Research "Demokritos," Athens, Greece.
Am J Physiol Cell Physiol. 2023 Sep 1;325(3):C633-C647. doi: 10.1152/ajpcell.00178.2023. Epub 2023 Jul 24.
The extracellular matrix (ECM) is a dynamic structural network that provides a physical scaffolding, as well as biochemical factors that maintain normal tissue homeostasis and thus its disruption is implicated in many pathological conditions. On the other hand, senescent cells express a particular secretory phenotype, affecting the composition and organization of the surrounding ECM and modulating their microenvironment. As accumulation of senescent cells may be linked to the manifestation of several age-related conditions, senescence-associated ECM alterations may serve as targets for novel anti-aging treatment modalities. Here, we will review characteristic changes in the ECM elicited by cellular senescence and we will discuss the complex interplay between ECM and senescent cells, in relation to normal aging and selected age-associated pathologies.
细胞外基质（ECM）是一种动态的结构网络，提供物理支架以及维持正常组织内稳态的生化因子，因此其破坏与许多病理状况有关。另一方面，衰老细胞表达一种特殊的分泌表型，影响周围 ECM 的组成和组织，并调节其微环境。由于衰老细胞的积累可能与几种与年龄相关的疾病的表现有关，因此与衰老相关的 ECM 改变可能成为新型抗衰老治疗方法的靶点。在这里，我们将回顾细胞衰老引起的 ECM 的特征变化，并讨论 ECM 与衰老细胞之间的复杂相互作用，涉及正常衰老和选定的与年龄相关的病理。
