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紫外线C辐射对兔钛种植体骨结合的组织形态学分析

Histomorphic Analysis of UV-C Radiation on Osseointegration of Titanium Implants in the Rabbits.

作者信息

Vafadoost Reza, Shabahangfar Mohammad Reza, Khoshzaban Ahad, Ahmadian Moghadam Hamid

机构信息

Researcher, Dept. of Periodontics, College of Dentistry, Islamic Azad University of Tehran Medical Sciences, Tehran, Iran.

Dept. of Periodontics, College of Dentistry, Islamic Azad University of Tehran Medical Sciences, Tehran, Iran.

出版信息

J Dent (Shiraz). 2022 Dec;23(4):489-497. doi: 10.30476/DENTJODS.2021.91574.1592.

DOI:10.30476/DENTJODS.2021.91574.1592
PMID:36718163
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9883626/
Abstract

STATEMENT OF THE PROBLEM

Unsuccessful implant integration leads to pain and implant mobility. Implant photo-functionalization by ultraviolet (UV) light has been suggested as a method that may stimulate osseointegration.

PURPOSE

This study was conducted to analyze the histopathological feature of the titanium implant surface upon treatment with UV-C wave.

MATERIALS AND METHOD

In this interventional study, twenty rabbits were enrolled. In the treatment groups, the titanium implants, irradiated earlier with UV-C for four hours laterally, were inserted in one of the femur bones. In the control group, the titanium implants without irradiation were inserted in the other femur bone of the rabbits. After two and four weeks, the animals were sacrificed, and then the samples were histologically and histo-morphometrically analyzed. In addition, the amounts of new bone formation, bleeding, and inflammation were recorded, and the data were subjected to statistical analysis.

RESULTS

The results confirmed that UV-C irradiation to titanium implants significantly improved new bone formation (p< 0.001). However, no significant new bone formation was observed between two and four weeks after implant insertion (p< 0.098).

CONCLUSION

The study results showed that irradiating titanium implants with UV-C for four hours significantly improves osseointegration and new bone formation but does not considerably affect inflammation or bleeding around the implant. The study suggests that UV-C radiation can increase the success rate of implant treatment.

摘要

问题陈述

种植体整合失败会导致疼痛和种植体松动。紫外线（UV）光对种植体进行光功能化处理被认为是一种可能刺激骨整合的方法。

目的

本研究旨在分析经紫外线C波处理后钛种植体表面的组织病理学特征。

材料与方法

在这项干预性研究中，纳入了20只兔子。在治疗组中，将预先经紫外线C横向照射4小时的钛种植体植入兔子的一侧股骨。在对照组中，将未照射的钛种植体植入兔子的另一侧股骨。在2周和4周后，处死动物，然后对样本进行组织学和组织形态计量学分析。此外，记录新骨形成、出血和炎症的量，并对数据进行统计分析。

结果

结果证实，对钛种植体进行紫外线C照射可显著改善新骨形成（p<0.001）。然而，在种植体植入后2周和4周之间未观察到显著的新骨形成（p<0.098）。

结论

研究结果表明，对钛种植体进行4小时的紫外线C照射可显著改善骨整合和新骨形成，但对种植体周围的炎症或出血影响不大。该研究表明，紫外线C辐射可提高种植治疗的成功率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee8/9883626/ab9dbd6f90e8/JDS-23-489-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee8/9883626/15c47f7f67fb/JDS-23-489-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee8/9883626/94c5a1a49e8c/JDS-23-489-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee8/9883626/118c70629adf/JDS-23-489-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee8/9883626/ab9dbd6f90e8/JDS-23-489-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee8/9883626/15c47f7f67fb/JDS-23-489-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee8/9883626/6e00046948c6/JDS-23-489-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee8/9883626/7cff38d706ca/JDS-23-489-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee8/9883626/ade198458f69/JDS-23-489-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee8/9883626/118c70629adf/JDS-23-489-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee8/9883626/ab9dbd6f90e8/JDS-23-489-g007.jpg

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本文引用的文献

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Clin Oral Implants Res. 2020 Sep;31(9):785-802. doi: 10.1111/clr.13627. Epub 2020 Jul 2.
2
Tuning of Titanium Microfiber Scaffold with UV-Photofunctionalization for Enhanced Osteoblast Affinity and Function.经紫外光光功能化调控的钛微纤维支架对成骨细胞亲和力和功能的增强作用。
Int J Mol Sci. 2020 Jan 23;21(3):738. doi: 10.3390/ijms21030738.
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Disinfectant Activity of A Portable Ultraviolet C Equipment.
便携式紫外线 C 设备的消毒活性。
Int J Environ Res Public Health. 2019 Nov 27;16(23):4747. doi: 10.3390/ijerph16234747.
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Influence of Titanium Oxide Pillar Array Nanometric Structures and Ultraviolet Irradiation on the Properties of the Surface of Dental Implants-A Pilot Study.二氧化钛柱状阵列纳米结构与紫外线照射对牙种植体表面性能的影响——一项初步研究
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The Effect of Ultraviolet Photofunctionalization on a Titanium Dental Implant with Machined Surface: An In Vitro and In Vivo Study.紫外线光功能化对机械加工表面钛牙种植体的影响：一项体外和体内研究。
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Impaired osteoblastic behavior and function on saliva-contaminated titanium and its restoration by UV treatment.唾液污染钛表面对成骨细胞行为和功能的影响及其经紫外线处理后的恢复。
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