经杀菌紫外线消毒器的紫外线-C 照射对阳极氧化钛种植体的影响：兔研究。

The effect of ultraviolet-C irradiation via a bactericidal ultraviolet sterilizer on an anodized titanium implant: a study in rabbits.

机构信息

Department of Prosthodontics and Dental Research Institute, Seoul National University Dental Hospital, Seoul, Korea.

出版信息

Int J Oral Maxillofac Implants. 2013 Jan-Feb;28(1):57-66. doi: 10.11607/jomi.2638.

DOI:10.11607/jomi.2638

PMID:23377048

Abstract

PURPOSE

After placement, titanium dental implants are conditioned by blood and tissue fluid. These initial processes are affected by the hydrophilicity of the implant. The hydrophilicity of titanium dioxide (TiO2) can be increased by ultraviolet (UV)-C irradiation. Anodic oxidation is an electrochemical treatment used to form TiO2 layers that are characterized by their thickness, roughness, and porosity on the surface of titanium implants. These oxide layers increase implant durability and performance. Therefore, the aim of this study was to investigate the effect of UV-C irradiation on the anodized titanium surface and the resultant tissue response.

MATERIALS AND METHODS

Twenty-five titanium disks and 56 screw-type implants were fabricated of commercially pure titanium and anodized. The samples were divided into a control group (anodized) and a test group (anodized and UV-C irradiated with a bactericidal UV sterilizer for 24 hours just prior to experimentation). The surface characteristics of the disks, including roughness, crystal phase of the oxide layer, chemical composition, and water contact angle, were then evaluated. Implants were placed into rabbit tibiae, and histomorphometric analysis was performed after healing periods of 4 and 12 weeks. The results were compared between groups.

RESULTS

The surface topography and phase of the oxide layer were not significantly different between test and control groups. Carbon surface impurities were noticeably decreased after UV-C irradiation, and water contact angle measurements were significantly lower (P < .001). After a healing period of 4 weeks, test implants showed higher values for both bone-to-implant contact and the amount of bone in the thread area of the implant (P < .01). No significant differences between groups were found for either histomorphometric measurement after 12 weeks.

CONCLUSIONS

UV-C irradiation of an anodized titanium implant, accomplished via a bactericidal UV sterilizer, promoted an early bone response in rabbit tibiae.

摘要

目的

钛牙种植体植入后，会被血液和组织液浸润。这些初始过程受种植体亲水性的影响。通过紫外线（UV）-C 照射可以提高二氧化钛（TiO2）的亲水性。阳极氧化是一种电化学处理方法，用于在钛种植体表面形成 TiO2 层，其特征在于厚度、粗糙度和表面孔隙率。这些氧化层提高了植入物的耐久性和性能。因此，本研究旨在探讨 UV-C 照射对阳极氧化钛表面和组织反应的影响。

材料与方法

采用商业纯钛制备了 25 个钛盘和 56 个螺丝型植入物，并进行阳极氧化处理。将样品分为对照组（阳极氧化）和实验组（阳极氧化后，用杀菌紫外线消毒器照射 24 小时，然后在实验前照射）。然后评估了圆盘的表面特性，包括粗糙度、氧化层的晶体相、化学成分和水接触角。将植入物植入兔胫骨中，在愈合 4 周和 12 周后进行组织形态计量学分析。对结果进行了组间比较。