Domingo J L, Paternain J L, Llobet J M, Corbella J
Laboratory of Toxicology and Biochemistry, Faculty of Medicine, University of Barcelona, Reus, Spain.
Res Commun Chem Pathol Pharmacol. 1987 Jul;57(1):129-32.
Aluminum nitrate was administered by gavage to four groups of pregnant Sprague-Dawley rats from the 14th day of gestation through 21 days of lactation at doses of 0, 180, 360 and 720 mg/kg/day. These doses did not produce overt fetotoxic effects. However, the growth of the offspring was significantly less from birth and during all the period of lactation for the higher doses of aluminum nitrate. Although very few toxic effects could be observed for the 180 mg/kg/day group (or 13 mg Al/kg/day), this quantity is similar to the amounts ingested by some people in special medical treatment (10 mg Al/kg/day). Therefore, it would seem that high amounts of aluminum should not be ingested during the periods of gestation.
从妊娠第14天至哺乳期第21天，通过灌胃法给四组怀孕的斯普拉格-道利大鼠施用硝酸铝，剂量分别为0、180、360和720毫克/千克/天。这些剂量未产生明显的胎儿毒性作用。然而，对于较高剂量的硝酸铝，后代从出生起以及在整个哺乳期的生长明显较慢。虽然在180毫克/千克/天组（或13毫克铝/千克/天）中几乎观察不到毒性作用，但这个量与一些接受特殊医学治疗的人摄入的量相似（10毫克铝/千克/天）。因此，在妊娠期似乎不应摄入大量铝。
