Bernuzzi V, Desor D, Lehr P R
Centre des Sciences de l'Environnement, Neurotoxicologie, Université de Metz, France.
Teratology. 1989 Jul;40(1):21-7. doi: 10.1002/tera.1420400104.
The oral treatment of pregnant rats by aluminum chloride or lactate at various doses was applied from day 1 to day 21 of gestation to determine its influence on mortality, weight evolution, and neuromotor maturation of their pups. No effect of treatment on litter size was detected, but an increased mortality appeared during the first week: treatment by aluminum lactate was less active than was an equivalent treatment by aluminum chloride. Weight was transitorily delayed, but the reversal of this effect could be attributed to the decrease of litter size. The neuromotor maturation of surviving pups treated with the two aluminum salts showed an important impairment during the first 2 weeks of postnatal life.
在妊娠第1天至第21天，对怀孕大鼠口服不同剂量的氯化铝或乳酸铝，以确定其对幼崽死亡率、体重变化和神经运动成熟的影响。未检测到处理对窝仔数有影响，但在第一周出现了死亡率增加的情况：乳酸铝处理的活性低于等量氯化铝处理。体重出现短暂延迟，但这种影响的逆转可归因于窝仔数的减少。用两种铝盐处理的存活幼崽在出生后的前两周神经运动成熟出现了严重受损。
