Jia Zou, Tian Kai, Zhong Yuanyuan, Wang Xiaoyun, Gao Suyue, Xu Wushuang, Li Ke, Wu Lijun
Department of Plastic and Aesthetic Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Department of Party and Administration Office, The Second Affiliated Hospital of Soochow University, Suzhou, China.
J Cosmet Dermatol. 2023 May;22(5):1536-1544. doi: 10.1111/jocd.15632. Epub 2023 Jan 31.
To investigate the efficacy and safety of broadband light (BBL) combined with intradermal injection of tranexamic acid for treating melasma.
120 women with melasma admitted to our hospital from January 2021 to April 2022 were randomly categorized into the following groups: control group, treated with 250 mg tranexamic acid given orally twice daily, except during menstruation; group I, treated with BBL (Sciton, Inc., USA) monthly; group II, received intradermal injections of tranexamic acid monthly; and group III, treated with BBL with intradermal injection of tranexamic acid monthly. Treatment in each group lasted three months. The MASI (Melasma Area Severity Index) and VISIA (Canfield VISIA Complexion Analysis) were used for evaluation.
After treatment course, MASI scores and VISIA brown spot and red zone ranking improved in all four groups (p < 0.05). The decrease in MASI scores and improvement rates of VISIA brown spot and red zone rankings were not significantly different among the control group, group I, and group II; however, the decreased MASI scores and improvement rates of VISIA brown spot and red zone rankings were significantly higher in group III than in the other three groups (p < 0.05).
The effect of BBL combined with the intradermal injection of TA in the treatment of melasma is remarkable. This combination therapy can be an alternative and effective treatment for managing melasma.
探讨强脉冲光（BBL）联合皮内注射氨甲环酸治疗黄褐斑的疗效和安全性。
将2021年1月至2022年4月我院收治的120例黄褐斑女性患者随机分为以下几组：对照组，除经期外，每日口服2次250mg氨甲环酸；第一组，每月接受强脉冲光（美国Sciton公司）治疗；第二组，每月接受氨甲环酸皮内注射；第三组，每月接受强脉冲光联合氨甲环酸皮内注射治疗。每组治疗持续3个月。采用黄褐斑面积和严重程度指数（MASI）及VISIA（Canfield VISIA肤色分析）进行评估。
治疗疗程结束后，四组患者的MASI评分、VISIA褐色斑和红色区域排名均有所改善（p<0.05）。对照组、第一组和第二组之间的MASI评分下降及VISIA褐色斑和红色区域排名改善率无显著差异；然而，第三组的MASI评分下降及VISIA褐色斑和红色区域排名改善率显著高于其他三组（p<0.05）。
强脉冲光联合氨甲环酸皮内注射治疗黄褐斑效果显著。这种联合治疗可作为治疗黄褐斑的一种有效替代方法。
