Stone Steven, Thoms-Rodriguez Camille-Ann, Cameron Jenene, Seah Christine, Stephenson-Clarke Stacy, Melano Roberto G
The University of the West Indies, Mona, Jamaica.
The University Hospital of the West Indies, Mona, Jamaica.
Microbiol Spectr. 2023 Jan 31;11(2):e0345922. doi: 10.1128/spectrum.03459-22.
We have investigated the prevalence of carbapenemase-producing uropathogens at the University Hospital of the West Indies, Jamaica. From 64 unique urine samples collected between January and March 2020, only 2 closely related Klebsiella pneumoniae (ST11, 14 SNPs of difference; no clear epidemiological links found between patients) were carbapenemase-producers. By whole-genome sequencing (WGS), was found on ~46 kb, IncX3 plasmid. These findings highlight the necessity for continuous surveillance of these pathogens in Jamaica. As the problem of antibiotic resistance continues to be a global problem, we hope to be able to shed further insight into what is happening within the Caribbean, from which there has been a paucity of data. The ability to appropriately tackle the problem of resistance requires surveillance from all territories, including resource limited settings. In this paper, we look at a mechanism of resistance that renders some critical antibiotics useless, including carbapenems, cephalosporins, and penicillin.
我们调查了牙买加西印度群岛大学医院产碳青霉烯酶尿路病原体的流行情况。在2020年1月至3月收集的64份独特尿液样本中，只有2株密切相关的肺炎克雷伯菌（ST11，有14个单核苷酸多态性差异；未发现患者之间有明确的流行病学联系）是产碳青霉烯酶菌株。通过全基因组测序（WGS）发现，（此处原文缺失关键信息）位于约46 kb的IncX3质粒上。这些发现凸显了在牙买加持续监测这些病原体的必要性。由于抗生素耐药性问题仍然是一个全球性问题，我们希望能够进一步深入了解加勒比地区的情况，该地区此前数据匮乏。要妥善解决耐药性问题，需要所有地区进行监测，包括资源有限的地区。在本文中，我们探讨了一种使一些关键抗生素（包括碳青霉烯类、头孢菌素类和青霉素）失效的耐药机制。
