与肉瘤预后和免疫浸润的关联。
Association of with prognosis and immune infiltration of sarcoma.
机构信息
Department of Orthopedics, People's Hospital of Pingchang County, Pingchang, Sichuan 636400, China.
Department of Orthopedics, Longhui People’s Hospital, Shaoyang, Hunan 422200, China.
出版信息
Aging (Albany NY). 2023 Jan 30;15(2):567-582. doi: 10.18632/aging.204503.
OBJECTIVE
This study was performed to explore the prognostic relevance of () in pan-cancer and explore the association between and immune infiltration of sarcoma.
RESULTS
Elevated expression of was detected in cancer tissues compared to normal tissue, which was confirmed in synovial sarcoma tissues with immunohistochemistry (IHC). Additionally, higher expression of was connected to worse outcomes of sarcoma, gastric cancer, breast cancer, liver cancer or ovarian cancer. Moreover, was positively connected to immune cell infiltrates in sarcoma. In addition, infiltrating immune cell markers including monocyte, TAM, M1 and M2 presented different -associated immune infiltration patterns.
CONCLUSION
The results from our study showed that was positively related to the prognosis and immunological status of sarcoma. could be a potential biomarker for prognosis and immune cell infiltrates in sarcoma.
METHODS
Several databases including ONCOMINE, GEPIA, and Kaplan-Meier Plotter were adopted to explore the expression pattern of in sarcoma, which was confirmed by IHC. The GEPIA and TIMER datasets were adopted to investigate the associations between and prognosis in various cancers, especially in sarcoma.
目的
本研究旨在探讨 () 在多种癌症中的预后相关性，并探讨与肉瘤免疫浸润的关系。
结果
免疫组织化学（IHC）证实，与正常组织相比，滑膜肉瘤组织中存在 () 表达升高。此外，较高的表达与肉瘤、胃癌、乳腺癌、肝癌或卵巢癌的不良预后相关。此外，与肉瘤中的免疫细胞浸润呈正相关。此外，浸润免疫细胞标志物包括单核细胞、TAM、M1 和 M2 呈现出不同的与相关的免疫浸润模式。
结论
我们的研究结果表明，与肉瘤的预后和免疫状态呈正相关。可能是肉瘤预后和免疫细胞浸润的潜在生物标志物。
方法
采用 ONCOMINE、GEPIA 和 Kaplan-Meier Plotter 等多个数据库探讨肉瘤中 () 的表达模式，并通过 IHC 进行验证。采用 GEPIA 和 TIMER 数据集探讨与各种癌症，特别是肉瘤中的预后之间的关系。
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