Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, China.
School of Medicine, Nankai University, Tianjin, China.
Int J Colorectal Dis. 2023 Jan 31;38(1):26. doi: 10.1007/s00384-022-04296-3.
Both the clinical manifestation and molecular characteristics of colorectal cancer (CRC) vary according to the anatomical site. We explored the risk factors for four groups of colorectal neoplasms (CRN) at different anatomical sites.
We extracted data from the database of Tianjin Colorectal Cancer Screening Program from 2010 to 2020. According to the CRN anatomical sites, patients were divided into four groups: the proximal colon group, the distal colon group, the rectum group, and the multiple colorectal sites. Binary logistic regression analysis was used to explore the differences in risk factors of CRN at different anatomical sites.
The numbers of patients with CRN in the proximal colon, distal colon, rectum, and multiple colorectal sites were 4023, 6920, 3657, and 7938, respectively. Male sex was associated with a higher risk from the proximal colon to the rectum. Advanced age and obesity were also significantly associated with overall colorectal CRN risk, but there were some differences between men and women. Smoking was associated with CRN risk only in the distal colon and rectum in both men and women. Frequent alcohol consumption and family history of CRC in first-degree relatives (FDRs) were associated with the risk of multisite colorectal CRN only in males.
We observed differences in advanced age, obesity, smoking, alcohol consumption, and family history of colorectal cancer at different anatomical sites of colorectal neoplasms. These factors vary by gender.
结直肠癌（CRC）的临床表现和分子特征因解剖部位而异。我们探讨了不同解剖部位结直肠肿瘤（CRN）四组的危险因素。
我们从 2010 年至 2020 年的天津结直肠癌筛查项目数据库中提取数据。根据 CRN 的解剖部位，患者被分为四组：近端结肠组、远端结肠组、直肠组和多个结直肠部位。采用二项逻辑回归分析探讨不同解剖部位 CRN 的危险因素差异。
近端结肠、远端结肠、直肠和多个结直肠部位的 CRN 患者数量分别为 4023、6920、3657 和 7938。男性从近端结肠到直肠的患病风险更高与性别有关。高龄和肥胖与总体结直肠 CRN 风险显著相关，但在男性和女性之间存在一些差异。吸烟仅与男性的远端结肠和直肠的 CRN 风险相关。女性频繁饮酒和一级亲属（FDRs）结直肠癌家族史仅与男性多部位结直肠 CRN 的风险相关。
我们观察到不同解剖部位结直肠肿瘤的高龄、肥胖、吸烟、饮酒和结直肠癌家族史存在差异，这些因素因性别而异。
