Servicio de Reumatología, Hospital Universitario Dr. Negrín, Las Palmas de Gran Canaria, Spain.
Servicio de Reumatología, Hospital Universitario de Canarias, Tenerife, Spain.
Clin Exp Rheumatol. 2023 Jul;41(7):1537-1543. doi: 10.55563/clinexprheumatol/mr4bka. Epub 2023 Jan 31.
Interleukin-6 (IL-6) has been implicated in the pathophysiology of rheumatoid arthritis (RA) and in the development of atherosclerosis in the general population. In the present work we aimed to study if IL-6 serum levels have an influence on factors associated with cardiovascular (CV) disease in a cohort of Spanish patients with RA.
Cross-sectional study that encompassed 407 patients with RA. Serum IL-6 levels were assessed. Multivariable analysis was performed to examine the relationship of IL-6 to subclinical carotid atherosclerosis and classic CV risk factors, including a comprehensive lipid molecule profile and indices of insulin resistance and beta-cell function.
Circulating levels of IL-6 showed a correlation with acute phase reactants, disease activity, and other features of RA. However, classic CV risk factors, lipid profile and indices of insulin resistance, as well as subclinical carotid atherosclerosis, were not associated with serum IL-6 levels.
Although a direct association between IL-6 levels and traditional CV risk factors and subclinical carotid atherosclerosis was not observed, circulating IL-6 was associated with disease activity and acute-phase reactants, which have been associated with an increased risk of CV in these patients.
白细胞介素-6（IL-6）已被认为与类风湿关节炎（RA）的病理生理学以及普通人群中的动脉粥样硬化的发展有关。在本研究中，我们旨在研究西班牙 RA 患者队列中血清 IL-6 水平是否对与心血管（CV）疾病相关的因素有影响。
这是一项包含 407 例 RA 患者的横断面研究。评估了血清 IL-6 水平。进行多变量分析以检查 IL-6 与亚临床颈动脉粥样硬化和经典 CV 危险因素之间的关系，包括全面的脂质分子谱以及胰岛素抵抗和β细胞功能的指数。
循环 IL-6 水平与急性期反应物、疾病活动度和 RA 的其他特征相关。然而，经典 CV 危险因素、血脂谱和胰岛素抵抗指数以及亚临床颈动脉粥样硬化与血清 IL-6 水平无关。
尽管未观察到 IL-6 水平与传统 CV 危险因素和亚临床颈动脉粥样硬化之间存在直接关联，但循环 IL-6 与疾病活动度和急性期反应物相关，这些因素与这些患者 CV 风险增加有关。
