单次屏气三维磁共振弹性成像描绘肥胖患者的肝纤维化和炎症。
Single Breath-Hold 3-Dimensional Magnetic Resonance Elastography Depicts Liver Fibrosis and Inflammation in Obese Patients.
机构信息
National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD.
From the School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
出版信息
Invest Radiol. 2023 Jun 1;58(6):413-419. doi: 10.1097/RLI.0000000000000952. Epub 2023 Jan 21.
OBJECTIVES
Three-dimensional (3D) magnetic resonance elastography (MRE) measures liver fibrosis and inflammation but requires several breath-holds that hamper clinical acceptance. The aim of this study was to evaluate the technical and clinical feasibility of a single breath-hold 3D MRE sequence as a means of measuring liver fibrosis and inflammation in obese patients.
METHODS
From November 2020 to December 2021, subjects were prospectively enrolled and divided into 2 groups. Group 1 included healthy volunteers (n = 10) who served as controls to compare the single breath-hold 3D MRE sequence with a multiple-breath-hold 3D MRE sequence. Group 2 included liver patients (n = 10) who served as participants to evaluate the clinical feasibility of the single breath-hold 3D MRE sequence in measuring liver fibrosis and inflammation. Controls and participants were scanned at 60 Hz mechanical excitation with the single breath-hold 3D MRE sequence to retrieve the magnitude of the complex-valued shear modulus (|G*| [kPa]), the shear wave speed (Cs [m/s]), and the loss modulus (G" [kPa]). The controls were also scanned with a multiple-breath-hold 3D MRE sequence for comparison, and the participants had histopathology (Ishak scores) for correlation with Cs and G".
RESULTS
For the 10 controls, 5 were female, and the mean age and body mass index were 33.1 ± 9.5 years and 23.0 ± 2.1 kg/m 2 , respectively. For the 10 participants, 8 were female, and the mean age and body mass index were 45.1 ± 16.5 years and 33.1 ± 4.0 kg/m 2 (obese range), respectively. All participants were suspected of having nonalcoholic fatty liver disease. Bland-Altman analysis of the comparison in controls shows there are nonsignificant differences in |G*|, Cs, and G" below 6.5%, suggesting good consensus between the 2 sequences. For the participants, Cs and G" correlated significantly with Ishak fibrosis and inflammation grades, respectively ( ρ = 0.95, P < 0.001, and ρ = 0.84, P = 0.002).
CONCLUSION
The single breath-hold 3D MRE sequence may be effective in measuring liver fibrosis and inflammation in obese patients.
目的
三维（3D）磁共振弹性成像（MRE）可测量肝纤维化和炎症，但需要多次屏气，这阻碍了其临床应用。本研究旨在评估单次屏气 3D MRE 序列作为一种测量肥胖患者肝纤维化和炎症的技术和临床可行性。
方法
2020 年 11 月至 2021 年 12 月，前瞻性纳入受试者并分为两组。第 1 组为健康志愿者（n=10），作为对照组，比较单次屏气 3D MRE 序列与多次屏气 3D MRE 序列。第 2 组为肝脏疾病患者（n=10），作为参与者，评估单次屏气 3D MRE 序列在测量肝纤维化和炎症方面的临床可行性。对照组和参与者均以 60 Hz 机械激发进行单次屏气 3D MRE 序列扫描，以获取复值剪切模量幅度（|G*| [kPa]）、剪切波速度（Cs [m/s]）和损耗模量（G" [kPa]）。对照组还进行了多次屏气 3D MRE 序列扫描进行比较，参与者还进行了肝组织病理学（Ishak 评分）检查，以与 Cs 和 G"进行相关性分析。
结果
10 名对照组中，女性 5 名，平均年龄和体重指数分别为 33.1±9.5 岁和 23.0±2.1 kg/m 2。10 名参与者中，女性 8 名，平均年龄和体重指数分别为 45.1±16.5 岁和 33.1±4.0 kg/m 2（肥胖范围）。所有参与者均怀疑患有非酒精性脂肪性肝病。对照组的 Bland-Altman 分析显示，|G*|、Cs 和 G"在 6.5%以下差异无统计学意义，表明两种序列具有良好的一致性。对于参与者，Cs 和 G"与 Ishak 纤维化和炎症分级分别显著相关（ρ=0.95，P<0.001，和 ρ=0.84，P=0.002）。
结论
单次屏气 3D MRE 序列可能有效测量肥胖患者的肝纤维化和炎症。
Zotero 插件