Division of Neurobiology, Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.
DNA Cell Biol. 2023 Mar;42(3):107-112. doi: 10.1089/dna.2022.0662. Epub 2023 Jan 31.
We recently demonstrated that prostaglandin production in brain endothelial cells is both necessary and sufficient for the generation of fever during systemic immune challenge. I here discuss this finding in light of the previous literature and point to some unresolved issues.
我们最近的研究表明,在系统性免疫挑战期间,脑内皮细胞中前列腺素的产生对于发热的产生既是必要的也是充分的。我在这里根据先前的文献讨论了这一发现,并指出了一些尚未解决的问题。