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基于各向异性磁阻 LaSrMnO 的高性能植入式传感器，用于生物医学应用。

High-Performance Implantable Sensors based on Anisotropic Magnetoresistive LaSrMnO for Biomedical Applications.

机构信息

Fundación IMDEA Nanociencia, Calle Faraday 9, Madrid 28049, Spain.

Faculty of Experimental Sciences, Universidad Francisco de Vitoria, Pozuelo de Alarcón, Madrid 28223, Spain.

出版信息

ACS Biomater Sci Eng. 2023 Feb 13;9(2):1020-1029. doi: 10.1021/acsbiomaterials.2c01147. Epub 2023 Jan 31.

DOI:10.1021/acsbiomaterials.2c01147
PMID:36720461
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9930082/
Abstract

We present the design, fabrication, and characterization of an implantable neural interface based on anisotropic magnetoresistive (AMR) magnetic-field sensors that combine reduced size and high performance at body temperature. The sensors are based on LaSrMnO (LSMO) as a ferromagnetic material, whose epitaxial growth has been suitably engineered to get uniaxial anisotropy and large AMR output together with low noise even at low frequencies. The performance of LSMO sensors of different film thickness and at different temperatures close to 37 °C has to be explored to find an optimum sensitivity of ∼400%/T (with typical detectivity values of 2 nT·Hz at a frequency of 1 Hz and 0.3 nT·Hz at 1 kHz), fitted for the detection of low magnetic signals coming from neural activity. Biocompatibility tests of devices consisting of submillimeter-size LSMO sensors coated by a thin poly(dimethyl siloxane) polymeric layer, both and , support their high suitability as implantable detectors of low-frequency biological magnetic signals emerging from heterogeneous electrically active tissues.

摘要

我们提出了一种基于各向异性磁阻（AMR）磁场传感器的可植入神经接口的设计、制造和特性，该传感器在体温下具有尺寸减小和高性能的特点。传感器基于 LaSrMnO（LSMO）作为铁磁材料，其外延生长经过适当设计，可获得单轴各向异性和大 AMR 输出，即使在低频下也具有低噪声。必须探索不同膜厚和接近 37°C 的温度下的 LSMO 传感器的性能，以找到最佳灵敏度约为 400%/T（典型的检测值在 1 Hz 时为 2 nT·Hz，在 1 kHz 时为 0.3 nT·Hz），适合检测来自神经活动的低磁信号。由亚毫米尺寸的 LSMO 传感器和涂覆有薄聚二甲基硅氧烷（PDMS）聚合物层组成的器件的生物相容性测试支持其作为从异质电活性组织中产生的低频生物磁信号的可植入探测器的高度适用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d293/9930082/7351babad37b/ab2c01147_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d293/9930082/486e22994cc8/ab2c01147_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d293/9930082/c06ac88d2fc7/ab2c01147_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d293/9930082/563e8e75c59b/ab2c01147_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d293/9930082/bca68236c20d/ab2c01147_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d293/9930082/d87adbaa2ed4/ab2c01147_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d293/9930082/7351babad37b/ab2c01147_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d293/9930082/486e22994cc8/ab2c01147_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d293/9930082/c06ac88d2fc7/ab2c01147_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d293/9930082/563e8e75c59b/ab2c01147_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d293/9930082/bca68236c20d/ab2c01147_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d293/9930082/d87adbaa2ed4/ab2c01147_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d293/9930082/7351babad37b/ab2c01147_0007.jpg

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