Measurement of Minute Liquid Volumes of Chiral Molecules Using In-Fiber Polarimetry.

We report an optofluidic method that enables to efficiently measure the enantiomeric excess of chiral molecules at low concentrations. The approach is to monitor the optical activity induced by a Kagome-lattice hollow-core photonic crystal fiber filled with a sub-μL volume of chiral compounds. The technique also allows monitoring the enzymatic racemization of R-mandelic acid.