整合素αβ表达与镓-氮杂环十二烷四乙酸-环甘氨酸-精氨酸-甘氨酸-天冬氨酸正电子发射断层扫描/计算机断层扫描（Ga-NODAGA-RGD PET/CT）以及葡萄糖代谢与氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（F-FDG PET/CT）在食管癌或食管胃交界癌中的比较
Comparison of integrin αβ expression with Ga-NODAGA-RGD PET/CT and glucose metabolism with F-FDG PET/CT in esophageal or gastroesophageal junction cancers.
作者信息
Dietz Matthieu, Dunet Vincent, Mantziari Styliani, Pomoni Anastasia, Dias Correia Ricardo, Testart Dardel Nathalie, Boughdad Sarah, Nicod Lalonde Marie, Treglia Giorgio, Schafer Markus, Schaefer Niklaus, Prior John O
机构信息
Nuclear Medicine and Molecular Imaging Department, Lausanne University Hospital, Rue du Bugnon 46, 1011, Lausanne, Switzerland.
INSERM U1060, CarMeN Laboratory, University of Lyon, Lyon, France.
出版信息
Eur J Hybrid Imaging. 2023 Feb 1;7(1):3. doi: 10.1186/s41824-023-00162-9.
BACKGROUND
The primary aims of this study were to compare in patients with esophageal or esophagogastric junction cancers the potential of Ga-NODAGA-RGD PET/CT with that of F-FDG PET/CT regarding tumoral uptake and distribution, as well as histopathologic examination.
METHODS
Ten Ga-NODAGA-RGD and ten F-FDG PET/CT were performed in nine prospectively included participants (1 woman; aged 58 ± 8.4 y, range 40-69 y). Maximum SUV (SUV) and metabolic tumor volumes (MTV) were calculated. The Mann-Whitney U test and Spearman correlation analysis (ρ) were used.
RESULTS
Ga-NODAGA-RGD PET/CT detected positive uptake in 10 primary sites (8 for primary tumors and 2 for local relapse suspicion), 6 lymph nodes and 3 skeletal sites. F-FDG PET/CT detected positive uptake in the same sites but also in 16 additional lymph nodes and 1 adrenal gland. On a lesion-based analysis, SUV of F-FDG was significantly higher than those of Ga-NODAGA-RGD (4.9 [3.7-11.3] vs. 3.2 [2.6-4.2] g/mL, p = 0.014). Only one participant showed a higher SUV in an osseous metastasis with Ga-NODAGA-RGD as compared to F-FDG (6.6 vs. 3.9 g/mL). Correlation analysis showed positive correlation between F-FDG and Ga-NODAGA-RGD PET parameters (ρ = 0.56, p = 0.012 for SUV, ρ = 0.78, p < 0.001 for lesion-to-background ratios and ρ = 0.58, p = 0.024 for MTV). We observed that F-FDG uptake was homogenous inside all the confirmed primary sites (n = 9). In contrast, Ga-NODAGA-RGD PET showed more heterogenous uptake in 6 out of the 9 confirmed primary sites (67%), seen mostly in the periphery of the tumor in 5 out of the 9 confirmed primary sites (56%), and showed slight extensions into perilesional structures in 5 out of the 9 confirmed primary sites (56%).
CONCLUSIONS
In conclusion, Ga-NODAGA-RGD has lower potential in the detection of esophageal or esophagogastric junction malignancies compared to F-FDG. However, the results suggest that PET imaging of integrin αβ expression may provide complementary information and could aid in tumor diversity and delineation.
TRIAL REGISTRATION
Trial registration: NCT02666547. Registered January 28, 2016-Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02666547 .
背景
本研究的主要目的是比较食管或食管胃交界癌患者中，镓标记的NODAGA-RGD PET/CT与氟代脱氧葡萄糖（F-FDG）PET/CT在肿瘤摄取、分布以及组织病理学检查方面的潜力。
方法
对9名前瞻性纳入的参与者（1名女性；年龄58±8.4岁，范围40-69岁）进行了10次镓标记的NODAGA-RGD和10次F-FDG PET/CT检查。计算了最大标准化摄取值（SUV）和代谢肿瘤体积（MTV）。采用曼-惠特尼U检验和斯皮尔曼相关性分析（ρ）。
结果
镓标记的NODAGA-RGD PET/CT在10个原发部位检测到阳性摄取（8个为原发性肿瘤，2个为怀疑局部复发）、6个淋巴结和3个骨骼部位。F-FDG PET/CT在相同部位检测到阳性摄取，但还在另外16个淋巴结和1个肾上腺中检测到。基于病灶的分析显示，F-FDG的SUV显著高于镓标记的NODAGA-RGD（4.9[3.7-11.3] vs. 3.2[2.6-4.2]g/mL，p = 0.014）。只有1名参与者在骨转移中镓标记的NODAGA-RGD的SUV高于F-FDG（6.6 vs. 3.9 g/mL）。相关性分析显示，F-FDG与镓标记的NODAGA-RGD PET参数之间呈正相关（SUV的ρ = 0.56，p = 0.012；病灶与背景比值的ρ = 0.78，p < 0.001；MTV的ρ = 0.58，p = 0.024）。我们观察到，F-FDG在所有确诊的原发部位（n = 9）内摄取均匀。相比之下，镓标记的NODAGA-RGD PET在9个确诊的原发部位中的6个（67%）显示摄取更不均匀，其中9个确诊的原发部位中的5个（56%）主要见于肿瘤周边，9个确诊的原发部位中的5个（56%）显示向病灶周围结构有轻微延伸。
结论
总之，与F-FDG相比，镓标记的NODAGA-RGD在检测食管或食管胃交界恶性肿瘤方面潜力较低。然而，结果表明整合素αβ表达的PET成像可能提供补充信息，并有助于肿瘤的鉴别和勾勒。
试验注册
试验注册：NCT02666547。2016年1月28日注册——回顾性注册，https://clinicaltrials.gov/ct2/show/NCT02666547 。
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