用镓标记的NODAGA-RGD正电子发射断层显像/计算机断层扫描（Ga-NODAGA-RGD PET/CT）对大动脉粥样硬化中的血管生成进行成像：与临床动脉粥样硬化性心血管疾病的关系
Imaging angiogenesis in atherosclerosis in large arteries with Ga-NODAGA-RGD PET/CT: relationship with clinical atherosclerotic cardiovascular disease.
作者信息
Dietz Matthieu, Kamani Christel H, Deshayes Emmanuel, Dunet Vincent, Mitsakis Periklis, Coukos George, Nicod Lalonde Marie, Schaefer Niklaus, Prior John O
机构信息
Nuclear Medicine and Molecular Imaging Department, Lausanne University Hospital, Rue du Bugnon 46, 1011, Lausanne, Switzerland.
Nuclear Medicine Department, Montpellier Cancer Institute (ICM), University of Montpellier, 208 Avenue des Apothicaires, 34298, Montpellier Cedex 5, France.
出版信息
EJNMMI Res. 2021 Aug 14;11(1):71. doi: 10.1186/s13550-021-00815-5.
BACKGROUND
Integrin alpha-V-beta-3 (αvβ3) pathway is involved in intraplaque angiogenesis and inflammation and represents a promising target for molecular imaging in cardiovascular diseases such as atherosclerosis. The aim of this study was to assess the clinical correlates of arterial wall accumulation of Ga-NODAGA-RGD, a specific αβ integrin ligand for PET.
MATERIALS AND METHODS
The data of 44 patients who underwent Ga-NODAGA-RGD PET/CT scans were retrospectively analyzed. Tracer accumulation in the vessel wall of major arteries was analyzed semi-quantitatively by blood-pool-corrected target-to-background ratios. Tracer uptake was compared with clinically documented atherosclerotic cardiovascular disease, cardiovascular risk factors and calcified plaque burden. Data were compared using the Mann-Whitney U test, Pearson correlation and Spearman correlation.
RESULTS
Ga-NODAGA-RGD arterial uptake was significantly higher in patients with previous clinically documented atherosclerotic cardiovascular disease (mean TBR 2.44 [2.03-2.55] vs. 1.81 [1.56-1.96], p = 0.001) and showed a significant correlation with prior cardiovascular or cerebrovascular event (r = 0.33, p = 0.027), BMI (ρ = 0.38, p = 0.01), plaque burden (ρ = 0.31, p = 0.04) and hypercholesterolemia (r = 0.31, p = 0.04).
CONCLUSIONS
Ga-NODAGA-RGD holds promise as a non-invasive marker of disease activity in atherosclerosis, providing information about intraplaque angiogenesis.
背景
整合素α-V-β-3（αvβ3）通路参与斑块内血管生成和炎症反应，是动脉粥样硬化等心血管疾病分子成像的一个有前景的靶点。本研究旨在评估用于正电子发射断层扫描（PET）的特异性αβ整合素配体镓标记的NODAGA-RGD在动脉壁积聚的临床相关性。
材料与方法
回顾性分析44例行镓标记的NODAGA-RGD PET/CT扫描患者的数据。通过血池校正的靶本底比值对主要动脉血管壁中的示踪剂积聚进行半定量分析。将示踪剂摄取情况与临床记录的动脉粥样硬化性心血管疾病、心血管危险因素和钙化斑块负荷进行比较。使用Mann-Whitney U检验、Pearson相关性分析和Spearman相关性分析对数据进行比较。
结果
既往有临床记录的动脉粥样硬化性心血管疾病患者的镓标记的NODAGA-RGD动脉摄取显著更高（平均靶本底比值2.44[2.03-2.55] vs. 1.81[1.56-1.96]，p = 0.001），且与既往心血管或脑血管事件（r = 0.33，p = 0.027）、体重指数（ρ = 0.38，p = 0.01）、斑块负荷（ρ = 0.31，p = 0.04）和高胆固醇血症（r = 0.31，p = 0.04）显著相关。
结论
镓标记的NODAGA-RGD有望成为动脉粥样硬化疾病活动的无创标志物，提供有关斑块内血管生成的信息。
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