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镓标记的NODAGA-RGD与F-FDG PET/CT对头颈部肿瘤血管生成成像的比较：一项初步研究

Head and neck tumors angiogenesis imaging with Ga-NODAGA-RGD in comparison to F-FDG PET/CT: a pilot study.

作者信息

Durante Steve, Dunet Vincent, Gorostidi François, Mitsakis Periklis, Schaefer Niklaus, Delage Judith, Prior John O

机构信息

Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Rue du Bugnon, 46, Lausanne, Switzerland.

Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

出版信息

EJNMMI Res. 2020 May 7;10(1):47. doi: 10.1186/s13550-020-00638-w.

DOI:10.1186/s13550-020-00638-w
PMID:32382869
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7205972/
Abstract

BACKGROUND

Angiogenesis plays an important role in head and neck squamous cell carcinoma (HNSCC) progression. This pilot study was designed to compare the distribution of Ga-NODAGA-RGD PET/CT for imaging αβ integrins involved in tumor angiogenesis to F-FDG PET/CT in patients with HNSCC.

MATERIAL AND METHODS

Ten patients (aged 58.4 ± 8.3 years [range, 44-73 years], 6 males, 4 females) with a total of 11 HNSCC were prospectively enrolled. Activity mapping and standard uptake values (SUV) from both Ga-NODAGA-RGD and F-FDG PET/CT scans were recorded for primary tumor and compared with the Wilcoxon signed-rank test. The relation between the SUV of both tracers was assessed using the Spearman correlation.

RESULTS

All HNSCC tumors were visible with both tracers. Quantitative analysis showed higher F-FDG SUV in comparison to Ga-NODAGA-RGD (14.0 ± 6.1 versus 3.9 ± 1.1 g/mL, p = 0.0017) and SUV (8.2 ± 3.1 versus 2.0 ± 0.8 g/mL, p = 0.0017). Both F-FDG and Ga-NODAGA-RGD uptakes were neither correlated with grade, HPV status nor p16 protein expression (p ≥ 0.17).

CONCLUSION

All HNSCC tumors were detected with both tracers with higher uptake with F-FDG, however. Ga-NODAGA-RGD has a different spatial distribution than F-FDG bringing different tumor information.

TRIAL REGISTRATION

NCT, NCT02666547. Registered 12.8.2012.

摘要

背景

血管生成在头颈部鳞状细胞癌（HNSCC）进展中起重要作用。本前瞻性研究旨在比较镓标记的NODAGA - RGD PET/CT对参与肿瘤血管生成的αβ整合素成像与氟代脱氧葡萄糖（F-FDG）PET/CT在HNSCC患者中的分布情况。

材料与方法

前瞻性纳入10例患者（年龄58.4±8.3岁[范围44 - 73岁]，男性6例，女性4例），共11处HNSCC。记录镓标记的NODAGA - RGD和F-FDG PET/CT扫描对原发性肿瘤的活性图谱及标准摄取值（SUV），并采用Wilcoxon符号秩检验进行比较。使用Spearman相关性评估两种示踪剂SUV之间的关系。

结果

两种示踪剂均能显示所有HNSCC肿瘤。定量分析显示，与镓标记的NODAGA - RGD相比，F-FDG的SUV更高（分别为14.0±6.1与3.9±1.1g/mL，p = 0.0017）以及SUV（分别为8.2±3.1与2.0±0.8g/mL，p = 0.0017）。F-FDG和镓标记的NODAGA - RGD摄取均与分级、人乳头瘤病毒（HPV）状态及p16蛋白表达无关（p≥0.17）。

结论

两种示踪剂均能检测到所有HNSCC肿瘤，但F-FDG摄取更高。镓标记的NODAGA - RGD与F-FDG具有不同的空间分布，可提供不同的肿瘤信息。

试验注册

NCT，NCT02666547。2012年8月12日注册。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfaf/7205972/527491611358/13550_2020_638_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfaf/7205972/e0e382ab2ab2/13550_2020_638_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfaf/7205972/807904861c5c/13550_2020_638_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfaf/7205972/527491611358/13550_2020_638_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfaf/7205972/e0e382ab2ab2/13550_2020_638_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfaf/7205972/23eb0196c262/13550_2020_638_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfaf/7205972/0d600b3a20e9/13550_2020_638_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfaf/7205972/764d6efbe7b0/13550_2020_638_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfaf/7205972/807904861c5c/13550_2020_638_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfaf/7205972/527491611358/13550_2020_638_Fig6_HTML.jpg

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