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住院的新冠肺炎患者循环血中骨形态发生蛋白9（BMP9）和磷酸化骨形态发生蛋白10（pBMP10）水平降低。

Reduced circulating BMP9 and pBMP10 in hospitalized COVID-19 patients.

作者信息

Dunmore Benjamin J, Upton Paul D, Auckland Kate, Samanta Romit J, Lyons Paul A, Smith Kenneth G C, Gräf Stefan, Summers Charlotte, Morrell Nicholas W

机构信息

Heart and Lung Research Institute University of Cambridge Cambridge UK.

Department of Medicine University of Cambridge School of Clinical Medicine Cambridge UK.

出版信息

Pulm Circ. 2023 Jan 1;13(1):e12192. doi: 10.1002/pul2.12192. eCollection 2023 Jan.

DOI:10.1002/pul2.12192
PMID:36721385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9881210/
Abstract

Similar to other causes of acute respiratory distress syndrome, coronavirus disease 2019 (COVID-19) is characterized by the aberrant expression of vascular injury biomarkers. We present the first report that circulating plasma bone morphogenetic proteins (BMPs), BMP9 and pBMP10, involved in vascular protection, are reduced in hospitalized patients with COVID-19.

摘要

与急性呼吸窘迫综合征的其他病因类似，2019冠状病毒病（COVID-19）的特征是血管损伤生物标志物表达异常。我们首次报告，参与血管保护的循环血浆骨形态发生蛋白（BMPs），即BMP9和pBMP10，在COVID-19住院患者中有所减少。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60dc/9881210/c81bd4012ac9/PUL2-13-e12192-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60dc/9881210/c81bd4012ac9/PUL2-13-e12192-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60dc/9881210/c81bd4012ac9/PUL2-13-e12192-g001.jpg

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Inflammation. 2022 Apr;45(2):800-811. doi: 10.1007/s10753-021-01585-x. Epub 2021 Oct 31.
2
Between inflammation and thrombosis: endothelial cells in COVID-19.在炎症与血栓之间：COVID-19 中的血管内皮细胞。
Eur Respir J. 2021 Sep 9;58(3). doi: 10.1183/13993003.00377-2021. Print 2021 Sep.
3
Homozygous GDF2 nonsense mutations result in a loss of circulating BMP9 and BMP10 and are associated with either PAH or an "HHT-like" syndrome in children.
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Mol Genet Genomic Med. 2021 Dec;9(12):e1685. doi: 10.1002/mgg3.1685. Epub 2021 Apr 9.
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Placental growth factor level in plasma predicts COVID-19 severity and in-hospital mortality.血浆胎盘生长因子水平可预测 COVID-19 严重程度和住院死亡率。
J Thromb Haemost. 2021 Jul;19(7):1823-1830. doi: 10.1111/jth.15339. Epub 2021 May 17.
5
Time course of endothelial dysfunction markers and mortality in COVID-19 patients: A pilot study.新冠病毒肺炎患者内皮功能障碍标志物的时间进程与死亡率：一项初步研究。
Clin Transl Med. 2021 Mar;11(3):e283. doi: 10.1002/ctm2.283.
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