Mauro Carolina Saori Ishii, Hassani Maryame Kadiri, Barone Monica, Esposito Maria Teresa, Calle Yolanda, Behrends Volker, Garcia Sandra, Brigidi Patrizia, Turroni Silvia, Costabile Adele
Department of Food Science and Technology State University of Londrina Londrina 86057-970 Brazil.
School of Life and Health Sciences University of Roehampton London SW15 4JD UK.
Int J Food Sci Technol. 2023 Jan 14. doi: 10.1111/ijfs.16274.
Cerrado and Pantanal plants can provide fruits with high nutritional value and antioxidants. This study aims to evaluate four fruit flours (from jatobá pulp, cumbaru almond, bocaiuva pulp and bocaiuva almond) and their effects on the gut microbiota in healthy (HD) and post-COVID-19 individuals (PC). An batch system was carried out, the microbiota was analysed by 16S rRNA amplicon sequencing and the short-chain fatty acids ratio was determined. Furthermore, the effect of jatobá pulp flour oil (JAO) on cell viability, oxidative stress and DNA damage was investigated in a myelo-monocytic cell line. Beyond confirming a microbiota imbalance in PC, we identified flour-specific effects: (i) reduction of with jatobá extract in PC samples; (ii) decrease in with jatoba and cumbaru flours; (iii) decreasing trend of and with all flours tested, with the exception of the bocaiuva almond in HD samples for and (iv) increase in and in PC samples with bocaiuva almond flour. JAO displayed antioxidant properties protecting cells from daunorubicin-induced cytotoxicity, oxidative stress and DNA damage. The promising microbiota-modulating abilities of some flours and the chemopreventive effects of JAO deserve to be further explored in human intervention studies.
塞拉多和潘塔纳尔湿地的植物能提供具有高营养价值和抗氧化剂的果实。本研究旨在评估四种果粉（来自jatobá果肉、cumbaru杏仁、bocaiuva果肉和bocaiuva杏仁）及其对健康个体（HD）和新冠康复个体（PC）肠道微生物群的影响。开展了分批系统实验，通过16S rRNA扩增子测序分析微生物群，并测定短链脂肪酸比例。此外，在髓单核细胞系中研究了jatobá果肉粉油（JAO）对细胞活力、氧化应激和DNA损伤的影响。除了确认PC组存在微生物群失衡外，我们还确定了果粉的特定作用：（i）PC样本中jatobá提取物可降低[具体指标未明确]；（ii）jatobá和cumbaru果粉可降低[具体指标未明确]；（iii）除HD样本中bocaiuva杏仁粉对[具体指标未明确]外，所有测试果粉均使[具体指标未明确]和[具体指标未明确]呈下降趋势；（iv）PC样本中bocaiuva杏仁粉可使[具体指标未明确]和[具体指标未明确]增加。JAO具有抗氧化特性，可保护细胞免受柔红霉素诱导的细胞毒性、氧化应激和DNA损伤。一些果粉有前景的微生物群调节能力以及JAO的化学预防作用值得在人体干预研究中进一步探索。
