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肠内微生物组和细胞因子谱在新冠后综合征中的表现。

Gut Microbiome and Cytokine Profiles in Post-COVID Syndrome.

机构信息

Department of Microbiology and Virology Named after Sh.I.Sarbasova, Astana Medical University, Astana 010000, Kazakhstan.

Laboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana 010000, Kazakhstan.

出版信息

Viruses. 2024 May 2;16(5):722. doi: 10.3390/v16050722.

DOI:10.3390/v16050722
PMID:38793604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11126011/
Abstract

Recent studies highlight the crucial role of the gut microbiome in post-infectious complications, especially in patients recovering from severe COVID-19. Our research aimed to explore the connection between gut microbiome changes and the cytokine profile of patients with post-COVID syndrome. Using 16S rRNA amplicon sequencing, we analyzed the composition of the gut microbiome in 60 COVID-19 patients over the course of one year. We also measured the levels of serum cytokines and chemokines using the Milliplex system. Our results showed that severe SARS-CoV-2 infection cases, especially those complicated by pneumonia, induce a pro-inflammatory microbial milieu with heightened presence of , , and . Furthermore, we found that post-COVID syndrome is characterized by a cross-correlation of various cytokines and chemokines MDC, IL-1b, Fractalkine, TNFa, FGF-2, EGF, IL-1RA, IFN-a2, IL-10, sCD40L, IL-8, Eotaxin, IL-12p40, and MIP-1b as well as a shift in the gut microbiome towards a pro-inflammatory profile. At the functional level, our analysis revealed associations with post-COVID-19 in homolactic fermentation, pentose phosphate, NAD salvage, and flavin biosynthesis. These findings highlight the intricate interplay between the gut microbiota, their metabolites, and systemic cytokines in shaping post-COVID symptoms. Unraveling the gut microbiome's role in post-infectious complications opens avenues for new treatments for those patients with prolonged symptoms.

摘要

最近的研究强调了肠道微生物组在感染后并发症中的关键作用，特别是在从严重 COVID-19 中康复的患者中。我们的研究旨在探索肠道微生物组变化与新冠后综合征患者细胞因子谱之间的联系。我们使用 16S rRNA 扩增子测序技术，在一年的时间里分析了 60 名 COVID-19 患者的肠道微生物组组成。我们还使用 Milliplex 系统测量了血清细胞因子和趋化因子的水平。我们的研究结果表明，严重的 SARS-CoV-2 感染病例，特别是那些伴有肺炎的病例，会诱导一种促炎的微生物环境，其中存在更高水平的、、和。此外，我们发现新冠后综合征的特征是各种细胞因子和趋化因子 MDC、IL-1b、Fractalkine、TNFa、FGF-2、EGF、IL-1RA、IFN-a2、IL-10、sCD40L、IL-8、Eotaxin、IL-12p40 和 MIP-1b 的交叉相关，以及肠道微生物组向促炎状态的转变。在功能水平上，我们的分析揭示了与新冠后相关的同型乳酸发酵、戊糖磷酸、NAD 挽救和黄素生物合成途径。这些发现强调了肠道微生物群、其代谢物和系统细胞因子在塑造新冠后症状中的复杂相互作用。揭示肠道微生物组在感染后并发症中的作用为那些症状持续时间长的患者提供了新的治疗途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e1e/11126011/9fa8a84b4429/viruses-16-00722-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e1e/11126011/aa96d892e6dd/viruses-16-00722-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e1e/11126011/0e72c8bd751d/viruses-16-00722-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e1e/11126011/83fb322c0b7f/viruses-16-00722-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e1e/11126011/00c4513846ba/viruses-16-00722-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e1e/11126011/1858e866a416/viruses-16-00722-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e1e/11126011/9fa8a84b4429/viruses-16-00722-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e1e/11126011/aa96d892e6dd/viruses-16-00722-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e1e/11126011/0e72c8bd751d/viruses-16-00722-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e1e/11126011/83fb322c0b7f/viruses-16-00722-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e1e/11126011/00c4513846ba/viruses-16-00722-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e1e/11126011/1858e866a416/viruses-16-00722-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e1e/11126011/9fa8a84b4429/viruses-16-00722-g006.jpg

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