Kim Ji Hyun, Ra Je Hyeon, Kang Heerim, Park Soo-Dong, Shim Jae-Jung, Lee Jung-Lyoul
R&BD Center, hy Co., Ltd., Gyeonggi 17086, Korea.
Prev Nutr Food Sci. 2022 Dec 31;27(4):414-422. doi: 10.3746/pnf.2022.27.4.414.
People often experience cognitive deterioration of various degrees, from early-stage mild cognitive impairment to severe cognitive decline. Cognitive deterioration is related to many diseases and studied to alleviated inflammation reaction or oxidative stress. In the present study, the levels of various memory-related proteins: brain-derived neurotrophic factor (BDNF), amyloid beta (Aβ) 42, Aβ40, interleukin-6 and tumor necrosis factor-alpha were measured. Among HP7 (HP7), Linn. (PO) and HP7 together with PO (HP7A), the HP7A group had the best effect on increasing BDNF expression and suppressing Aβ40 expression. Also, we measured the protective effect on scopolamine-induced cognitive decline in mice. In the acquisition test, the HP7A group most reliably relieved cognitive decline from days 2 to 5 of scopolamine injection. When the probe test was performed on the day 6 of scopolamine injection, the HP7A group had the shortest escape latency. Based on the results of the Morris water maze tasks, we suggest that HP7A is most useful for ameliorating cognitive decline. It is suggested that the HP7A ameliorating scopolamine-induced cognitive decline via the increase of BDNF expression and the suppression of Aβ40 expression.
人们经常会经历不同程度的认知衰退，从早期的轻度认知障碍到严重的认知下降。认知衰退与许多疾病相关，并且研究旨在减轻炎症反应或氧化应激。在本研究中，测量了各种与记忆相关的蛋白质水平：脑源性神经营养因子（BDNF）、β-淀粉样蛋白（Aβ）42、Aβ40、白细胞介素-6和肿瘤坏死因子-α。在HP7（HP7）、林奈（PO）以及HP7与PO联合使用（HP7A）中，HP7A组在增加BDNF表达和抑制Aβ40表达方面效果最佳。此外，我们测量了其对东莨菪碱诱导的小鼠认知衰退的保护作用。在习得性测试中，HP7A组在东莨菪碱注射第2天至第5天最可靠地缓解了认知衰退。在东莨菪碱注射第6天进行探针测试时，HP7A组的逃避潜伏期最短。基于莫里斯水迷宫任务的结果，我们认为HP7A对改善认知衰退最有效。提示HP7A通过增加BDNF表达和抑制Aβ40表达来改善东莨菪碱诱导的认知衰退。
