质子激活氯离子通道：生理学与疾病。

Proton-Activated Chloride Channel: Physiology and Disease.

机构信息

School of Health Science and Engineering, University of Shanghai for Science and Technology, 200093 Shanghai, China.

Chongming Hospital Affiliated to Shanghai University of Medicine and Health Sciences, 202150 Shanghai, China.

出版信息

Front Biosci (Landmark Ed). 2023 Jan 16;28(1):11. doi: 10.31083/j.fbl2801011.

DOI:10.31083/j.fbl2801011

PMID:36722267

Abstract

The maintenance of intracellular and extracellular pH relies on multiple ion transporters/channels. Proton-activated chloride channel (PAC) precisely regulates extracellular and early/late endosomal pH by transporting chloride ion (Cl-) across membranes and has been shown to be implicated in pH imbalance under hypoxic conditions, such as the acidic microenvironments of cancer and ischemia. In this article, the phenotypic characteristics, molecular mechanisms, physiology of PAC and its role in cancer, ischemic stroke and hypoxia will be discussed in order to provide some clues for developing potential therapeutic strategies.

摘要

细胞内和细胞外 pH 的维持依赖于多种离子转运体/通道。质子激活氯离子通道 (PAC) 通过跨膜转运氯离子 (Cl-) 精确调节细胞外和早期/晚期内体 pH，并已被证明与缺氧条件下的 pH 失衡有关，如癌症和缺血的酸性微环境。本文将讨论 PAC 的表型特征、分子机制、生理学及其在癌症、缺血性中风和缺氧中的作用，以期为开发潜在的治疗策略提供一些线索。