College of Pharmacy, Shenzhen Technology University, 518118 Shenzhen, Guangdong, China.
Jiangxi Key Laboratory of Bioprocess Engineering and Co-Innovation Center for In-Vitro Diagnostic Reagents and Devices of Jiangxi Province, College of Life Sciences, Jiangxi Science and Technology Normal University, 330013 Nanchang, Jiangxi, China.
Front Biosci (Landmark Ed). 2023 Jan 10;28(1):6. doi: 10.31083/j.fbl2801006.
The liver is the most significant metabolic organ in the body and plays an important role in lipid metabolism. Liver lipid metabolism disorders cause hepatic diseases such as hepatitis, hepatic cirrhosis, and hepatoma. Autophagy is a process of generating energy and building blocks by degrading redundant or damaged proteins and organelles. Thus, it helps in the maintenance of cellular homeostasis. Recent discoveries revealed that lipophagy plays a vital role in hepatic cellular homeostasis and lipid metabolism. Its imbalance is always associated with the perturbation of lipid metabolism in the liver. This article reviewed the molecular mechanisms involved in lipophagy and the interaction between lipophagy and hepatic lipid metabolism. Increasing evidence suggests that lipophagy is an effective method to resolve liver diseases.
肝脏是人体最重要的代谢器官，在脂质代谢中起着重要作用。肝脏脂质代谢紊乱会导致肝炎、肝硬化和肝癌等肝脏疾病。自噬是通过降解多余或受损的蛋白质和细胞器来产生能量和构建块的过程。因此，它有助于维持细胞内的稳态。最近的发现表明，脂噬在肝细胞内稳态和脂质代谢中起着至关重要的作用。其失衡总是与肝脏脂质代谢的紊乱有关。本文综述了脂噬涉及的分子机制以及脂噬与肝脂质代谢之间的相互作用。越来越多的证据表明，脂噬是解决肝脏疾病的有效方法。
