载脂蛋白 E ε4 与 LOAD 的症状较早出现相关，但与 EOAD 的症状较晚出现相关。
APOE ε4 is associated with earlier symptom onset in LOAD but later symptom onset in EOAD.
机构信息
Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Indiana Alzheimer's Disease Research Center, Indianapolis, Indiana, USA.
出版信息
Alzheimers Dement. 2023 May;19(5):2212-2217. doi: 10.1002/alz.12955. Epub 2023 Feb 1.
Abstract
BACKGROUND
We studied the effect of apolipoprotein E (APOE) ε4 status and sex on age of symptom onset (AO) in early- (EO) and late- (LO) onset Alzheimer's disease (AD).
METHOD
A total of 998 EOAD and 2562 LOAD participants from the National Alzheimer's Coordinating Center (NACC) were included. We used analysis of variance to examine AO differences between sexes and APOE genotypes and the effect of APOE ε4, sex, and their interaction on AO in EOAD and LOAD, separately.
RESULTS
APOE ε4 carriers in LOAD had younger AO and in EOAD had older AO. Female EOAD APOE ε4 carriers had older AO compared to non-carriers (P < 0.0001). There was no difference for males. Both male and female LOAD APOE ε4 carriers had younger AO relative to non-carriers (P < 0.0001).
CONCLUSION
The observed earlier AO in EOAD APOE ε4 non-carriers relative to carriers, particularly in females, suggests the presence of additional AD risk variants.
摘要
背景
我们研究了载脂蛋白 E（APOE）ε4 状态和性别对早发性（EO）和晚发性（LO）阿尔茨海默病（AD）发病年龄（AO）的影响。
方法
共纳入来自国家阿尔茨海默病协调中心（NACC）的 998 名 EOAD 和 2562 名 LOAD 参与者。我们使用方差分析来检查性别和 APOE 基因型之间的 AO 差异，以及 APOE ε4、性别及其在 EOAD 和 LOAD 中的相互作用对 AO 的影响。
结果
LOAD 中的 APOE ε4 携带者的 AO 较年轻，而 EOAD 中的 APOE ε4 携带者的 AO 较年长。与非携带者相比，女性 EOAD APOE ε4 携带者的 AO 较年长（P<0.0001）。男性则无差异。LOAD 中的男性和女性 APOE ε4 携带者的 AO 均较非携带者年轻（P<0.0001）。
结论
与携带者相比，EOAD APOE ε4 非携带者的 AO 较早，特别是在女性中，提示存在其他 AD 风险变异。
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