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异构体和细胞状态特异性的载脂蛋白E稳态与功能。

Isoform- and cell-state-specific APOE homeostasis and function.

作者信息

Lindner Karina, Gavin Anne-Claude

机构信息

Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

出版信息

Neural Regen Res. 2024 Nov 1;19(11):2456-2466. doi: 10.4103/NRR.NRR-D-23-01470. Epub 2024 Jan 31.

DOI:10.4103/NRR.NRR-D-23-01470
PMID:38526282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11090418/
Abstract

Apolipoprotein E is the major lipid transporter in the brain and an important player in neuron-astrocyte metabolic coupling. It ensures the survival of neurons under stressful conditions and hyperactivity by nourishing and detoxifying them. Apolipoprotein E polymorphism, combined with environmental stresses and/or age-related alterations, influences the risk of developing late-onset Alzheimer's disease. In this review, we discuss our current knowledge of how apolipoprotein E homeostasis, i.e. its synthesis, secretion, degradation, and lipidation, is affected in Alzheimer's disease.

摘要

载脂蛋白E是大脑中的主要脂质转运蛋白，也是神经元 - 星形胶质细胞代谢偶联中的重要参与者。它通过滋养和解毒神经元来确保其在应激条件和活动亢进状态下的存活。载脂蛋白E基因多态性，结合环境压力和/或与年龄相关的改变，会影响晚发性阿尔茨海默病的发病风险。在这篇综述中，我们讨论了目前关于阿尔茨海默病中载脂蛋白E稳态，即其合成、分泌、降解和脂化如何受到影响的知识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7aba/11090418/c08b47e27ec1/NRR-19-2456-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7aba/11090418/cdfaa64bd04a/NRR-19-2456-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7aba/11090418/935ac3279ffe/NRR-19-2456-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7aba/11090418/c08b47e27ec1/NRR-19-2456-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7aba/11090418/cdfaa64bd04a/NRR-19-2456-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7aba/11090418/935ac3279ffe/NRR-19-2456-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7aba/11090418/c08b47e27ec1/NRR-19-2456-g003.jpg

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Trends Endocrinol Metab. 2023 Aug;34(8):430-445. doi: 10.1016/j.tem.2023.05.002. Epub 2023 Jun 24.
3
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Neural Regen Res. 2025 Jul 1;20(7):1883-1899. doi: 10.4103/NRR.NRR-D-24-00048. Epub 2024 Jul 10.
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