Universidade Federal de Goiás, Goiânia, GO, Brazil.
Scholarship holder at the Fundação de Amparo à Pesquisa no Estado de Goiás, Brazil.
Rev Lat Am Enfermagem. 2023 Jan-Dec;31:e3765. doi: 10.1590/1518-8345.6107.3765.
to identify the vaccination and serological status against hepatitis B among community health workers; to vaccinate against hepatitis B virus and to evaluate the immune response of susceptible workers.
phase I, cross-sectional and descriptive study, among community health workers in a capital city of the Midwest region, through a self-administered questionnaire, checking of vaccination cards, and blood collection for testing of serological markers for hepatitis B. Phase II, cohort study carried out in vaccinated non-immune workers identified in phase I. They received one dose of vaccine (challenge dose) and serological testing.
a total of 109 workers participated in the study. Most had vaccination record (97; 89.0%) and vaccination completeness (75; 77.3%), while the isolated anti-HBs (Antibodies against hepatitis B virus) marker was detected in 78 (71.6%) workers. The prevalence of hepatitis B virus exposure was 8.2%. Of the ten non-immune vaccinated workers, after challenge dose, one remained susceptible.
although most workers are vaccinated and show immunological response to hepatitis B, susceptibility after challenge dose was identified. Therefore, it is necessary to have a surveillance program of the vaccination situation and serological status for this virus, to promote these workers' safety.
确定社区卫生工作者的乙型肝炎疫苗接种和血清学状况；接种乙型肝炎病毒疫苗，并评估易感工作者的免疫反应。
I 期为横断面描述性研究，在中西部首府城市的社区卫生工作者中进行，通过自填式问卷、接种卡检查和采集血液检测乙型肝炎血清学标志物。II 期为在 I 期发现的未免疫接种的疫苗接种易感工作者的队列研究。他们接种一剂疫苗（挑战剂量）并进行血清学检测。
共有 109 名工人参加了这项研究。大多数工人都有接种记录（97 名；89.0%）和接种完成率（75 名；77.3%），而 78 名工人（71.6%）检测到了孤立的抗乙型肝炎病毒（HBs）抗体标志物。乙型肝炎病毒暴露的患病率为 8.2%。在 10 名未免疫接种的疫苗接种工人中，挑战剂量后，有 1 人仍为易感者。
尽管大多数工人接种了疫苗，并对乙型肝炎产生了免疫反应，但仍发现了挑战剂量后的易感性。因此，有必要对该病毒的疫苗接种情况和血清学状况进行监测，以确保这些工人的安全。
