Area Brain Aging and Mental Health, Department of Psychiatry, Columbia University Irving Medical Center, New York, New York, USA.
The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA.
Alzheimers Dement. 2023 Apr;19(4):1592-1597. doi: 10.1002/alz.12946. Epub 2023 Feb 1.
Mild to moderate exercise may decrease Alzheimer's disease (AD) risk, but the effects of vigorous, regular physical exercise remain unclear.
Two patients with initial diagnoses of amnestic mild cognitive impairment (MCI) demonstrated positive AD biomarkers throughout 16 and 8 years of follow-up, with final diagnoses of mild AD and amnestic MCI, respectively.
Patient 1 was diagnosed with amnestic MCI at age 64. Neuropsychological testing, magnetic resonance imaging (MRI), fluorodeoxyglucose-positron emission tomography (FDG-PET), amyloid imaging PET, and cerebrospinal fluid (CSF) biomarkers during follow-ups remained consistent with AD. By age 80, progression was minimal with Montreal Cognitive Assessment (MoCA) 26 of 30. Patient 2 was diagnosed with amnestic MCI at age 72. Neuropsychological testing, MRI, FDG-PET, and amyloid imaging PET during follow-ups remained consistent with AD. At age 80, MoCA was 27 of 30 with no clinical progression. Both patients regularly performed vigorous, regular exercise that increased after retirement/work reduction.
Vigorous, regular exercise may slow disease progression in biomarker-positive amnestic MCI and mild AD.
适度到剧烈的运动可能会降低阿尔茨海默病（AD）的风险，但剧烈、有规律的体育锻炼的效果仍不清楚。
两名患者最初被诊断为遗忘型轻度认知障碍（MCI），在 16 年和 8 年的随访中均表现出 AD 的阳性生物标志物，最终分别被诊断为轻度 AD 和遗忘型 MCI。
患者 1 于 64 岁时被诊断为遗忘型 MCI。神经心理学测试、磁共振成像（MRI）、氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）、淀粉样蛋白成像 PET 和脑脊液（CSF）生物标志物在随访中均与 AD 一致。到 80 岁时，蒙特利尔认知评估（MoCA）得分为 30 分中的 26 分，进展甚微。患者 2 于 72 岁时被诊断为遗忘型 MCI。神经心理学测试、MRI、FDG-PET 和淀粉样蛋白成像 PET 在随访中均与 AD 一致。到 80 岁时，MoCA 得分为 30 分中的 27 分，无临床进展。两名患者均定期进行剧烈、有规律的运动，退休/减少工作后运动量增加。
剧烈、有规律的运动可能会减缓生物标志物阳性的遗忘型 MCI 和轻度 AD 的疾病进展。
