Shanxi Medical University School and Hospital of Stomatology, Taiyuan 030001, Shanxi, China.
Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan 030001, Shanxi, China.
Nanoscale. 2023 Feb 16;15(7):3106-3119. doi: 10.1039/d2nr05951g.
Bone tissue engineering (BTE), based on the perfect combination of seed cells, scaffold materials and growth factors, has shown unparalleled potential in the treatment of bone defects and related diseases. As the site of cell attachment, proliferation and differentiation, scaffolds composed of biomaterials play a crucial role in BTE. Over the past years, carbon dots (CDs), a new type of carbon-based nanomaterial, have attracted extensive research attention due to their good biocompatibility, unique optical properties, and abundant functional groups. This paper reviews recent research progress in the use of CDs in the field of BTE. Firstly, different preparation methods of CDs are summarized. Then, the properties and categories of CDs applied in BTE are described in detail. Subsequently, the applications of CDs in BTE, including osteogenesis, fluorescence tracing, phototherapy and antibacterial activity, are presented. Finally, the challenges and future perspectives of CDs in BTE are briefly discussed to give a comprehensive picture of CDs. This review provides a theoretical basis and advanced design strategies for the application of CDs in BTE.
基于种子细胞、支架材料和生长因子的完美结合的骨组织工程（BTE）在治疗骨缺损和相关疾病方面显示出无与伦比的潜力。作为细胞附着、增殖和分化的部位，由生物材料组成的支架在 BTE 中起着至关重要的作用。近年来，由于良好的生物相容性、独特的光学特性和丰富的官能团，碳点（CDs）作为一种新型碳基纳米材料引起了广泛的研究关注。本文综述了 CDs 在 BTE 领域的研究进展。首先，总结了 CDs 的不同制备方法。然后，详细描述了应用于 BTE 的 CDs 的特性和类别。随后，介绍了 CDs 在 BTE 中的应用，包括成骨作用、荧光示踪、光疗和抗菌活性。最后，简要讨论了 CDs 在 BTE 中的挑战和未来展望，以全面了解 CDs。本综述为 CDs 在 BTE 中的应用提供了理论基础和先进的设计策略。
