Department of Prosthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran; Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Int J Biol Macromol. 2024 Jan;254(Pt 1):127556. doi: 10.1016/j.ijbiomac.2023.127556. Epub 2023 Oct 25.
The creation of a suitable scaffold is a crucial step in the process of bone tissue engineering (BTE). The scaffold, acting as an artificial extracellular matrix, plays a significant role in determining the fate of cells by affecting their proliferation and differentiation in BTE. Therefore, careful consideration should be given to the fabrication approach and materials used for scaffold preparation. Natural polypeptides such as gelatin and collagen have been widely used for this purpose. The unique properties of nanoparticles, which vary depending on their size, charge, and physicochemical properties, have demonstrated potential in solving various challenges encountered in BTE. Therefore, nanocomposite biomaterials consisting of polymers and nanoparticles have been extensively used for BTE. Gelatin has also been utilized in combination with other nanomaterials to apply for this purpose. Composites of gelatin with various types of nanoparticles are particularly promising for creating scaffolds with superior biological and physicochemical properties. This review explores the use of nanocomposite biomaterials based on gelatin and various types of nanoparticles together for applications in bone tissue engineering.
构建合适的支架是骨组织工程（BTE）过程中的关键步骤。支架作为人工细胞外基质，通过影响细胞在 BTE 中的增殖和分化，对细胞命运起着重要作用。因此，需要仔细考虑支架制备的制造方法和材料。天然多肽如明胶和胶原已被广泛用于此目的。纳米粒子的独特性质（取决于其大小、电荷和物理化学性质）在解决 BTE 中遇到的各种挑战方面表现出了潜力。因此，由聚合物和纳米粒子组成的纳米复合生物材料已被广泛用于 BTE。明胶也已与其他纳米材料结合使用以达到此目的。明胶与各种类型的纳米粒子的复合材料在构建具有优异的生物和物理化学性能的支架方面特别有前景。本综述探讨了基于明胶和各种类型的纳米粒子的纳米复合生物材料在骨组织工程中的应用。
