Wu Juan, Chi Ya-Qi, Yan Yu-Jia, Ji Meng-Zhen, Chen Xuan, Yang Xue-Qin, Gao Yuan, Zou Qin, Zou Ling, Li Xi-Yu
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Analytical and Testing Center, Sichuan University, Chengdu, 610064, China.
Nanoscale. 2023 Feb 23;15(8):3940-3951. doi: 10.1039/d2nr06795a.
Hydroxyapatite (HA) is a biomimetic biomaterial that has been widely used in bone repair for many years. However, the increased risk of infection after surgery and long-time tracing for the material distribution and degradation during bone reconstruction remain challenges in the clinic. Zinc (Zn) is considered as an indispensable microelement for humans and is characterized with antibacterial action and osteogenic activity. Terbium (Tb), a rare-earth element, emits stable fluorescence under ultraviolet light. Here, Tb/Zn co-doped hydroxyapatite (HA:Tb/Zn) was prepared to synchronously realize the antibacterial effect, osteogenic activity, and long-time tracing property. We found that HA:Tb/Zn had a strong antibacterial effect on both Gram-positive and Gram-negative clinical infectious bacteria, as well as improved osteogenic activity. HA:Tb/Zn also displayed stable green fluorescence and , which indicated great potential for recognizing the material changes during the bone reconstruction process. The combination of the ternary functions is of great significance to control the overuse of antibiotics and realize long-time tracing, and provide a versatile design on biomaterials in bone repair.
羟基磷灰石（HA）是一种仿生生物材料，多年来已广泛应用于骨修复。然而，手术后感染风险增加以及在骨重建过程中对材料分布和降解进行长期追踪仍是临床上面临的挑战。锌（Zn）被认为是人体不可或缺的微量元素，具有抗菌作用和成骨活性。铽（Tb）是一种稀土元素，在紫外光下发出稳定的荧光。在此，制备了Tb/Zn共掺杂羟基磷灰石（HA:Tb/Zn），以同步实现抗菌效果、成骨活性和长期追踪性能。我们发现，HA:Tb/Zn对革兰氏阳性和革兰氏阴性临床感染细菌均具有强大的抗菌作用，同时还改善了成骨活性。HA:Tb/Zn还显示出稳定的绿色荧光，这表明其在识别骨重建过程中的材料变化方面具有巨大潜力。这三种功能的结合对于控制抗生素的过度使用和实现长期追踪具有重要意义，并为骨修复中的生物材料提供了一种通用设计。
