Nishizawa Shigeru, Ouchi Hitoshi, Suzuki Hiroto, Ohnishi Takuma, Sasaki Shingo, Oyagi Yu, Kanakogi Masaki, Matsumura Yoshitaka, Nakagawa Shunsuke, Asakawa Tomohiro, Egi Masahiro, Inai Makoto, Yoshimura Fumihiko, Takita Ryo, Kan Toshiyuki
School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
Org Biomol Chem. 2023 Feb 22;21(8):1653-1656. doi: 10.1039/d2ob02325c.
The stereo-controlled total synthesis of (-)-domoic acid is described. The critical construction of the C1'-C2' -configuration was accomplished by taking advantage of an unsaturated lactam structure. The side chain fragment was introduced in the final stages of synthesis through a modified Julia-Kocieński reaction, aiming for its efficient derivatization.
